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Lysophosphatidic acid (<jats:styled-content style=\"fixed-case\">LPA<\/jats:styled-content>) and sphingosine 1\u2010phosphate (<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>) are representative lysophospholipids. Accumulating evidence suggests that, acting as intercellular mediators, these and other lysophospholipids may play important roles in physiological and pathological situations. This review discusses the possible involvement of <jats:styled-content style=\"fixed-case\">LPA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content> in reproductive processes, with a focus on the regulatory mechanisms of pregnancy maintenance. As <jats:styled-content style=\"fixed-case\">LPA<\/jats:styled-content> promotes prostaglandin synthesis, mediators in the <jats:styled-content style=\"fixed-case\">LPA<\/jats:styled-content> pathway may also play a significant role in implantation and parturition. <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content> signaling is thought to be essential in vascular formation within the uteroplacental unit and in fetomaternal immunologic interactions. Derangements in either one of these lysophospholipid signaling pathways could result in pregnancy complications that may include implantation failure, preeclampsia, and preterm labor.<\/jats:p>","DOI":"10.1111\/aji.12239","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T11:33:03Z","timestamp":1396351983000},"page":"182-191","source":"Crossref","is-referenced-by-count":32,"title":["Emerging Roles for Lysophospholipid Mediators in Pregnancy"],"prefix":"10.1111","volume":"72","author":[{"given":"Takeshi","family":"Nagamatsu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine The University of Tokyo Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Iwasawa\u2010Kawai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine The University of Tokyo Bunkyo\u2010ku Tokyo 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