{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:01:51Z","timestamp":1783105311115,"version":"3.54.6"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T00:00:00Z","timestamp":1397779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>The transcobalamin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (<jats:italic><jats:styled-content style=\"fixed-case\">TCN<\/jats:styled-content>2<\/jats:italic>) 776C&gt;G polymorphism has been reported to be a genetic risk factor for idiopathic recurrent spontaneous abortion (<jats:styled-content style=\"fixed-case\">RSA<\/jats:styled-content>). However, the sample size in previous studies was small, and other <jats:italic><jats:styled-content style=\"fixed-case\">TCN<\/jats:styled-content>2<\/jats:italic> polymorphisms have not been studied. Moreover, the <jats:italic><jats:styled-content style=\"fixed-case\">TCN<\/jats:styled-content>2<\/jats:italic> 67A&gt;G and 776C&gt;G polymorphisms, and the transcobalamin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> receptor (<jats:italic><jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>blR\/<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>320<\/jats:italic>) 1104C&gt;T polymorphism, have demonstrated associations with immune responses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Three hundred and seventy\u2010eight <jats:styled-content style=\"fixed-case\">RSA<\/jats:styled-content> patients who had at least two consecutive spontaneous abortions were enrolled. Two hundred and seven control subjects were collected from a convenience sample. Polymerase chain reaction and restriction fragment length polymorphism analysis were performed to identify the <jats:italic><jats:styled-content style=\"fixed-case\">TCN<\/jats:styled-content>2<\/jats:italic> 67A&gt;G and 776C&gt;G polymorphisms, and the <jats:italic><jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>blR<\/jats:italic> 1104C&gt;T polymorphism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">RSA<\/jats:styled-content> patients showed significantly different frequencies of the <jats:italic><jats:styled-content style=\"fixed-case\">TCN<\/jats:styled-content>2<\/jats:italic> 67<jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> genotypes compared with control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:italic><jats:styled-content style=\"fixed-case\">TCN<\/jats:styled-content>2<\/jats:italic> 67G allele is a possible risk factor for idiopathic <jats:styled-content style=\"fixed-case\">RSA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12256","type":"journal-article","created":{"date-parts":[[2014,4,19]],"date-time":"2014-04-19T09:33:51Z","timestamp":1397900031000},"page":"337-346","source":"Crossref","is-referenced-by-count":14,"title":["Transcobalamin <scp>II<\/scp> (<i><scp>TCN<\/scp>2<\/i> 67A&gt;G and <i><scp>TCN<\/scp>2<\/i> 776C&gt;G) and Transcobalamin <scp>II<\/scp> Receptor (<i><scp>TC<\/scp>blR<\/i> 1104C&gt;T) Polymorphisms in Korean Patients with Idiopathic Recurrent Spontaneous Abortion"],"prefix":"10.1111","volume":"72","author":[{"given":"Hyun Seok","family":"Kim","sequence":"first","affiliation":[{"name":"Institute for Clinical Research CHA Bundang Medical Center CHA University Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute for Clinical Research CHA Bundang Medical Center CHA University Seongnam South Korea"},{"name":"Department of Biomedical Science College of Life Science CHA University Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Joo","family":"Jeon","sequence":"additional","affiliation":[{"name":"Institute for Clinical Research CHA Bundang Medical Center CHA University Seongnam South Korea"},{"name":"Department of Biomedical Science College of Life Science CHA University Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HyungChul","family":"Rah","sequence":"additional","affiliation":[{"name":"Institute for Clinical Research CHA Bundang Medical Center CHA University Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Sik","family":"Lee","sequence":"additional","affiliation":[{"name":"Fertility Center of CHA 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