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Innate immune responses against microorganisms at the maternal\u2010fetal interface may have a significant impact on the success of pregnancy, as intrauterine infections have been shown to be strongly associated with certain complications of pregnancy. At the maternal\u2010fetal interface, <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>s are expressed not only in the immune cells but also in non\u2010immune cells such as trophoblasts and decidual cells; moreover, their expression patterns vary according to the stage of pregnancy. Here, we will update potential functions of <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>s in these cells, their recognition and response to microorganisms, and their involvement in the innate immunity. The impact of <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>\u2010mediated innate immune response will be discussed via animal model studies, as well as clinical observations.<\/jats:p>","DOI":"10.1111\/aji.12258","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T07:31:01Z","timestamp":1398238261000},"page":"192-205","source":"Crossref","is-referenced-by-count":110,"title":["Toll\u2010like Receptors at the Maternal\u2010Fetal Interface in Normal Pregnancy and Pregnancy Complications"],"prefix":"10.1111","volume":"72","author":[{"given":"Kaori","family":"Koga","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gentaro","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The University of Tokyo Tokyo 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