{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T16:42:10Z","timestamp":1793292130603,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T00:00:00Z","timestamp":1399507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01ES018872"],"award-info":[{"award-number":["R01ES018872"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Previous studies have investigated the utility of inflammation markers as predictors of preterm birth, but none have compared trends in levels between uncomplicated and preterm pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>We explored longitudinal changes in plasma cytokines, including <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010, and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1, as well as C\u2010reactive protein in pregnant women from a nested case\u2013control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 was associated with increased odds of spontaneous preterm birth, defined by presentation of spontaneous preterm labor and\/or preterm premature rupture of the membranes. Associations were strongest later in pregnancy. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 was associated with increased odds of placentally mediated preterm birth, defined by presentation with preeclampsia or intrauterine growth restriction, and odds ratios were also highest near the end of pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal inflammation markers were associated with increased risk of preterm birth, and relationships differed by etiology of preterm delivery and gestational age at sample collection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12265","type":"journal-article","created":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T09:16:59Z","timestamp":1399540619000},"page":"326-336","source":"Crossref","is-referenced-by-count":140,"title":["Longitudinal Profiling of Inflammatory Cytokines and C\u2010reactive Protein during Uncomplicated and Preterm Pregnancy"],"prefix":"10.1111","volume":"72","author":[{"given":"Kelly K.","family":"Ferguson","sequence":"first","affiliation":[{"name":"Department of Environmental Health Sciences University of Michigan School of Public Health Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"McElrath","sequence":"additional","affiliation":[{"name":"Division of Maternal and Fetal Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin\u2010Hsiu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Michigan School of Public Health Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhramar","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Michigan School of Public Health Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Meeker","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences University of Michigan School of Public Health Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,8]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"HowsonC KinneyM LawnJ eds.:Born too soon: the global action report on preterm birth. 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