{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:37:06Z","timestamp":1758926226068,"version":"3.37.3"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T00:00:00Z","timestamp":1399507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003958","name":"Dutch Technology Foundation STW","doi-asserted-by":"crossref","award":["10704"],"award-info":[{"award-number":["10704"]}],"id":[{"id":"10.13039\/501100003958","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Changes in the systemic immune response are found in preeclampsia. This may be related to high extracellular adenosine triphosphate (<jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>) levels. The question arose whether <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content> could affect immune responses in pregnancy. Previously, we investigated whether <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content> affected monocyte activation and subpopulations. Here, we investigated <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>\u2010induced changes in other immune cell populations in pregnant rats, systemically and in the kidney, an affected organ in preeclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Using flow cytometry or immunohistochemistry, blood and kidney leukocytes were studied in pregnant and non\u2010pregnant rats at different intervals after <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content> or saline infusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adenosine triphosphate (<jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>) infusion induced increased peripheral blood non\u2010classical monocytes and decreased <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> lymphocyte subsets in pregnant rats only, higher glomerular macrophage and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> lymphocyte numbers in non\u2010pregnant animals 1\u00a0day after infusion, and higher glomerular macrophage numbers in pregnant rats 6\u00a0days after infusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adenosine triphosphate (<jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>) infusion in pregnant rats induced a pregnancy\u2010specific inflammatory response. Increased <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content> levels could potentially contribute to development of the inflammatory response of preeclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12267","type":"journal-article","created":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T09:16:37Z","timestamp":1399540597000},"page":"305-316","source":"Crossref","is-referenced-by-count":7,"title":["Extracellular Adenosine Triphosphate Affects Systemic and Kidney Immune Cell Populations in Pregnant Rats"],"prefix":"10.1111","volume":"72","author":[{"given":"Floor","family":"Spaans","sequence":"first","affiliation":[{"name":"Division of Medical Biology Department of Pathology and Medical Biology University Medical Center Groningen and University of Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbro N.","family":"Melgert","sequence":"additional","affiliation":[{"name":"Division of Medical Biology Department of 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