{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T17:30:41Z","timestamp":1786815041469,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T00:00:00Z","timestamp":1402444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Shijiazhuang Maternal and Obstetric Hospital"},{"name":"March of Dimes Global Network for Maternal and Infant Health"},{"name":"Peking University Center of Medical Genetics"},{"name":"New York State Office for People with Developmental Disabilities"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Spontaneous abortion (<jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>) occurs before 20 gestational weeks. Approximately, half of recurrent <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> has no identifiable cause. No report has yet been investigated the possible involvement of lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> in pregnancy loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>Sixteen pairs of pregnancies with spontaneous abortions (<jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>) and induced abortions (<jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>) were studied. Embryonic sacs and decidua were collected for each pregnancy. A Human Lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> Array was employed to profile genomewide lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s, which were then validated by <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Differentially expressed lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s were identified. Biological pathways were categorized into six major groups: infection and inflammation, metabolism, signaling and transcriptional regulation, smooth muscle contraction, cell process, and coagulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Infection and inflammation pathways regulated by lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s were determined as the predominant pathogenetic factors underlying the <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>. Finding that antisense lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s have been either up\u2010 or down\u2010regulated suggests that they may have both <jats:italic>cis\u2010<\/jats:italic> and <jats:italic>trans<\/jats:italic>\u2010regulations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12275","type":"journal-article","created":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T10:25:23Z","timestamp":1402482323000},"page":"359-375","source":"Crossref","is-referenced-by-count":55,"title":["Lnc<scp>RNA<\/scp>\u2010regulated Infection and Inflammation Pathways Associated with Pregnancy Loss: Genome Wide Differential Expression of lnc<scp>RNA<\/scp>s in Early Spontaneous Abortion"],"prefix":"10.1111","volume":"72","author":[{"given":"Hong","family":"Wang","sequence":"first","affiliation":[{"name":"Shijiazhuang Obstetric and Maternal Health Hospital Shijiazhuang China"},{"name":"Chinese Alliance of Translational Medicine for Maternal and Children's Health Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingying","family":"Cao","sequence":"additional","affiliation":[{"name":"Shijiazhuang Obstetric and Maternal Health Hospital Shijiazhuang China"},{"name":"Chinese Alliance of Translational Medicine for Maternal and Children's Health Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ge","sequence":"additional","affiliation":[{"name":"Shijiazhuang Obstetric and Maternal Health Hospital Shijiazhuang China"},{"name":"Chinese Alliance of Translational Medicine for Maternal and Children's Health Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Shijiazhuang Obstetric and Maternal Health Hospital Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Ma","sequence":"additional","affiliation":[{"name":"Shijiazhuang Obstetric and Maternal Health Hospital Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuciu","family":"Meng","sequence":"additional","affiliation":[{"name":"Shijiazhuang Obstetric and Maternal Health Hospital Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Shijiazhuang Obstetric and Maternal Health Hospital Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shijiazhuang Obstetric and Maternal Health Hospital Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Liu","sequence":"additional","affiliation":[{"name":"Shijiazhuang Obstetric and Maternal Health Hospital Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Li","sequence":"additional","affiliation":[{"name":"Shijiazhuang Obstetric and Maternal Health Hospital Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Children's Hospital of Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Zhong","sequence":"additional","affiliation":[{"name":"Hunter College High School New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weina","family":"Ju","sequence":"additional","affiliation":[{"name":"New York State Institute for Basic Research in Developmental Disabilities Staten Island NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund C.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"New York State Institute for Basic Research in Developmental Disabilities Staten Island NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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