{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:50:13Z","timestamp":1791269413177,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T00:00:00Z","timestamp":1401926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology, Japan","doi-asserted-by":"crossref","award":["22591840"],"award-info":[{"award-number":["22591840"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Problem<\/jats:title>Chronic endometritis (CE<\/jats:styled-content>) is a local inflammatory condition with unusual plasmacyte infiltration in the endometrial stromal area. CE<\/jats:styled-content> is frequently found in infertile women with repeated implantation failure (RIF<\/jats:styled-content>). In this study, we comprehensively investigated the endometrial immunoglobulin (Ig) subclass expression in infertile women suffering from RIF<\/jats:styled-content> with versus without CE<\/jats:styled-content>.<\/jats:p><\/jats:sec>Method of study<\/jats:title>Endometrial biopsy specimens obtained from 28 infertile women with RIF<\/jats:styled-content> and CE<\/jats:styled-content> (the RIF<\/jats:styled-content>\u2010CE<\/jats:styled-content> group), 23 infertile women with RIF<\/jats:styled-content> but without CE<\/jats:styled-content> (the RIF<\/jats:styled-content>\u2010non\u2010CE<\/jats:styled-content> group), and 22 proven fertile women undergoing hysterectomy for benign endometrial pathology (the control group) were immunostained for Ig subclass expression.<\/jats:p><\/jats:sec>Results<\/jats:title>The density of IgM+, IgA1<\/jats:sub>+, IgA2<\/jats:sub>+, IgG1<\/jats:sub>+, and IgG2<\/jats:sub>+ stromal cells were significantly higher in the RIF<\/jats:styled-content>\u2010CE<\/jats:styled-content> group than that in the RIF<\/jats:styled-content>\u2010non\u2010CE<\/jats:styled-content> and control group. The density of IgG2<\/jats:sub>+ stromal cells was significantly higher than that of any other Ig subclass\u2010positive cells (P<\/jats:italic>\u00a0<\u00a00.045) in the RIF<\/jats:styled-content>\u2010CE<\/jats:styled-content> group. In serial section staining, the immunoreactivity for CD<\/jats:styled-content>138 and Ig subclasses in the endometrial stroma was detectable in adjacent cells of some specimens in the RIF<\/jats:styled-content>\u2010CE<\/jats:styled-content> group.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The endometrium of infertile women with RIF<\/jats:styled-content>\u2010CE<\/jats:styled-content> was characterized by increase in IgM, IgA, and IgG expression and predominance of IgG2<\/jats:sub> over other Ig subclasses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12277","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T07:06:42Z","timestamp":1401952002000},"page":"386-391","source":"Crossref","is-referenced-by-count":76,"title":["Comprehensive Endometrial Immunoglobulin Subclass Analysis in Infertile Women Suffering from Repeated Implantation Failure with or without Chronic Endometritis"],"prefix":"10.1111","volume":"72","author":[{"given":"Kotaro","family":"Kitaya","sequence":"first","affiliation":[{"name":"IVF Center Oak Clinic Nishinari\u2010ku Osaka Japan"},{"name":"Department of Anatomy and Cell Science Kansai Medical University Moriguchi Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Tada","sequence":"additional","affiliation":[{"name":"IVF Center Oak Clinic Nishinari\u2010ku Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terumi","family":"Hayashi","sequence":"additional","affiliation":[{"name":"IVF Center Oak Clinic Nishinari\u2010ku Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagiri","family":"Taguchi","sequence":"additional","affiliation":[{"name":"IVF Center Oak Clinic Nishinari\u2010ku Osaka 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