{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T09:45:23Z","timestamp":1775209523697,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":403,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Reprod Immunol"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1111\/aji.12298","type":"journal-article","created":{"date-parts":[[2014,7,25]],"date-time":"2014-07-25T05:37:19Z","timestamp":1406266639000},"page":"504-514","source":"Crossref","is-referenced-by-count":48,"title":["Interleukin-18 and Interferon Gamma Levels in Preeclampsia: A Systematic Review and Meta-analysis"],"prefix":"10.1111","volume":"72","author":[{"given":"Yan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology; West China Second University Hospital; Sichuan University; Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Forensic DNA laboratory; Public security bureau of Beijing' Haidian; Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenming","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology; West China Second University Hospital; Sichuan University; Chengdu China"},{"name":"Sichuan University-The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine; West China Institute of Women and Children's Health; West China Second University Hospital; Sichuan University; Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology; West China Second University Hospital; Sichuan University; Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,25]]},"reference":[{"key":"10.1111\/aji.12298-BIB0001|aji12298-cit-0001","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0029-7844(96)00135-4","article-title":"Pregnancy-related mortality in the United States, 1987-1990","volume":"88","author":"Berg","year":"1996","journal-title":"Obstet Gynecol"},{"key":"10.1111\/aji.12298-BIB0002|aji12298-cit-0002","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0002-9378(99)70239-5","article-title":"Preeclampsia: an excessive maternal inflammatory response to pregnancy","volume":"180","author":"Redman","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"10.1111\/aji.12298-BIB0003|aji12298-cit-0003","doi-asserted-by":"crossref","first-page":"8522","DOI":"10.4049\/jimmunol.177.12.8522","article-title":"Decidual NK cells alter in vitro first trimester extravillous cytotrophoblast migration: a role for IFN-gamma","volume":"177","author":"Hu","year":"2006","journal-title":"J Immunol"},{"key":"10.1111\/aji.12298-BIB0004|aji12298-cit-0004","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0301-2115(02)00350-0","article-title":"Lymphocyte subset distribution and cytokine secretion in third trimester decidua in normal pregnancy and preeclampsia","volume":"109","author":"Wilczynski","year":"2003","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1111\/aji.12298-BIB0005|aji12298-cit-0005","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/378088a0","article-title":"Cloning of a new cytokine that induces IFN-gamma production by T cells","volume":"378","author":"Okamura","year":"1995","journal-title":"Nature"},{"key":"10.1111\/aji.12298-BIB0006|aji12298-cit-0006","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/meth.1999.0837","article-title":"Interleukin-18","volume":"19","author":"Dinarello","year":"1999","journal-title":"Methods"},{"key":"10.1111\/aji.12298-BIB0007|aji12298-cit-0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1020506300324","article-title":"Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1)","volume":"19","author":"Fantuzzi","year":"1999","journal-title":"J Clin Immunol"},{"key":"10.1111\/aji.12298-BIB0008|aji12298-cit-0008","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev.immunol.19.1.423","article-title":"Interleukin-18 regulates both Th1 and Th2 responses","volume":"19","author":"Nakanishi","year":"2001","journal-title":"Annu Rev Immunol"},{"key":"10.1111\/aji.12298-BIB0009|aji12298-cit-0009","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0029-7844(00)00895-4","article-title":"Placental apoptosis in preeclampsia","volume":"96","author":"Allaire","year":"2000","journal-title":"Obstet Gynecol"},{"key":"10.1111\/aji.12298-BIB0010|aji12298-cit-0010","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0165-0378(03)00048-2","article-title":"Implantation: can immunological parameters of implantation failure be of interest for pre-eclampsia?","volume":"59","author":"Chaouat","year":"2003","journal-title":"J Reprod Immunol"},{"key":"10.1111\/aji.12298-BIB0011|aji12298-cit-0011","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1046\/j.8755-8920.2003.00112.x","article-title":"Cytokine secretion patterns of NK cells and macrophages in early human pregnancy decidua and blood: implications for suppressor macrophages in decidua","volume":"50","author":"Lidstrom","year":"2003","journal-title":"Am J Reprod Immunol"},{"key":"10.1111\/aji.12298-BIB0012|aji12298-cit-0012","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1084\/jem.192.2.F1","article-title":"Role of uterine natural killer cells and interferon gamma in placental development","volume":"192","author":"Redline","year":"2000","journal-title":"J Exp Med"},{"key":"10.1111\/aji.12298-BIB0013|aji12298-cit-0013","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.placenta.2004.10.016","article-title":"Induction of murine spiral artery modification by recombinant human interferon-gamma","volume":"26","author":"Monk","year":"2005","journal-title":"Placenta"},{"key":"10.1111\/aji.12298-BIB0014|aji12298-cit-0014","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jri.2008.10.003","article-title":"Serum levels of YKL-40 and interleukin-18 and their relationship to disease severity in patients with preeclampsia","volume":"79","author":"Seol","year":"2009","journal-title":"J Reprod Immunol"},{"key":"10.1111\/aji.12298-BIB0015|aji12298-cit-0015","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.preghy.2011.07.003","article-title":"Interleukin-18 concentrations in pregnancies complicated by preeclampsia with and without IUGR: a comparison with normotensive pregnant women with isolated IUGR and healthy pregnant women","volume":"1","author":"Laskowska","year":"2011","journal-title":"Pregnancy Hypertension"},{"key":"10.1111\/aji.12298-BIB0016|aji12298-cit-0016","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/cbf.1503","article-title":"Interleukin-18 and gestosis: correlation with Helicobacter pylori seropositivity","volume":"26","author":"Pugliese","year":"2008","journal-title":"Cell Biochem Funct"},{"key":"10.1111\/aji.12298-BIB0017|aji12298-cit-0017","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1600-0412.2011.01134.x","article-title":"Longitudinal measurement of cytokines in pre-eclamptic and normotensive pregnancies","volume":"90","author":"Kronborg","year":"2011","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1111\/aji.12298-BIB0018|aji12298-cit-0018","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.cellimm.2013.06.012","article-title":"IL-10, TNF-alpha & IFN-gamma: potential early biomarkers for preeclampsia","volume":"283","author":"Kumar","year":"2013","journal-title":"Cell Immunol"},{"key":"10.1111\/aji.12298-BIB0019|aji12298-cit-0019","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3109\/08923979909007125","article-title":"Evaluation of nonspecific immunity and plasma levels of interferon-gamma, interleukin-6 and tumor necrosis factor-alpha in preeclampsia","volume":"21","author":"Munno","year":"1999","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"10.1111\/aji.12298-BIB0020|aji12298-cit-0020","first-page":"2","article-title":"Plasma IL-17, IL-35, interferon-gamma, SOCS3 and TGF-beta levels in pregnant women with preeclampsia, and their relation with severity of disease","volume":"2","author":"Ozkan","year":"2013","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1111\/aji.12298-BIB0021|aji12298-cit-0021","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0165-0378(00)00058-9","article-title":"IL-18 in pregnancy; the elevation of IL-18 in maternal peripheral blood during labour and complicated pregnancies","volume":"47","author":"Ida","year":"2000","journal-title":"J Reprod Immunol"},{"key":"10.1111\/aji.12298-BIB0022|aji12298-cit-0022","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1067\/mob.2003.349","article-title":"Interleukin-18 in the plasma of women with preeclampsia","volume":"188","author":"Adams","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1111\/aji.12298-BIB0023|aji12298-cit-0023","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3109\/10641955.2013.827203","article-title":"Combined biomarkers evaluation for diagnosing kidney injury in preeclampsia","volume":"32","author":"Xiao","year":"2013","journal-title":"Hypertens Pregnancy"},{"key":"10.1111\/aji.12298-BIB0024|aji12298-cit-0024","first-page":"1","article-title":"Serum levels of IL-18, IL-12 and TH-1\/TH-2 ratio in patients with pre-eclampsia","volume":"18","author":"El-Kabarity","year":"2011","journal-title":"Egypt J Immunol"},{"key":"10.1111\/aji.12298-BIB0025|aji12298-cit-0025","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/pd.4129","article-title":"Maternal serum cytokines at 30-33\u00a0weeks in the prediction of preeclampsia","volume":"33","author":"Mosimann","year":"2013","journal-title":"Prenat Diagn"},{"key":"10.1111\/aji.12298-BIB0026|aji12298-cit-0026","first-page":"179","article-title":"Serum cytokines profiles in Iranian patients with preeclampsia","volume":"4","author":"Mansouri","year":"2007","journal-title":"Iran J Immunol"},{"key":"10.1111\/aji.12298-BIB0027|aji12298-cit-0027","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2288-5-13","article-title":"Estimating the mean and variance from the median, range, and the size of a sample","volume":"5","author":"Hozo","year":"2005","journal-title":"BMC Med Res Methodol"},{"key":"10.1111\/aji.12298-BIB0028|aji12298-cit-0028","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3109\/00016340903576020","article-title":"Plasma interleukin-18 (IL-18) levels are correlated with antioxidant vitamin coenzyme Q(10) in preeclampsia","volume":"89","author":"Roland","year":"2010","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1111\/aji.12298-BIB0029|aji12298-cit-0029","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jri.2004.09.003","article-title":"Serum and placental interleukin-18 are elevated in preeclampsia","volume":"65","author":"Huang","year":"2005","journal-title":"J Reprod Immunol"},{"key":"10.1111\/aji.12298-BIB0030|aji12298-cit-0030","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1016\/j.cca.2011.06.042","article-title":"Serum heat shock protein 70 levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in women with preeclampsia","volume":"412","author":"Molvarec","year":"2011","journal-title":"Clin Chim Acta"},{"key":"10.1111\/aji.12298-BIB0031|aji12298-cit-0031","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jsgi.2005.02.005","article-title":"The predominant Th1 cytokine profile in maternal plasma of preeclamptic women is not reflected in the choriodecidual and fetal compartments","volume":"12","author":"Arriaga-Pizano","year":"2005","journal-title":"J Soc Gynecol Investig"},{"key":"10.1111\/aji.12298-BIB0032|aji12298-cit-0032","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"10.1111\/aji.12298-BIB0033|aji12298-cit-0033","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"10.1111\/aji.12298-BIB0034|aji12298-cit-0034","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"key":"10.1111\/aji.12298-BIB0035|aji12298-cit-0035","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1080\/10641950802601245","article-title":"Cytokines profiles in Sudanese women with preeclampsia","volume":"28","author":"Bakheit","year":"2009","journal-title":"Hypertens Pregnancy"},{"key":"10.1111\/aji.12298-BIB0036|aji12298-cit-0036","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.3109\/14767058.2011.648233","article-title":"Plasma IL-4, IL-8, IL-12, interferon-gamma and CRP levels in pregnant women with preeclampsia, and their relation with severity of disease and fetal birth weight","volume":"25","author":"Cemgil Arikan","year":"2012","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1111\/aji.12298-BIB0037|aji12298-cit-0037","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1600-0897.1998.tb00372.x","article-title":"Plasma interleukin-12 is elevated in patients with preeclampsia","volume":"39","author":"Daniel","year":"1998","journal-title":"Am J Reprod Immunol"},{"key":"10.1111\/aji.12298-BIB0038|aji12298-cit-0038","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jri.2005.10.007","article-title":"Cytokine mapping of sera from women with preeclampsia and normal pregnancies","volume":"70","author":"Jonsson","year":"2006","journal-title":"J Reprod Immunol"},{"key":"10.1111\/aji.12298-BIB0039|aji12298-cit-0039","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00404-002-0436-y","article-title":"Connection between human leucocyte antigens D region and T helper cytokines in preeclampsia","volume":"269","author":"Omu","year":"2004","journal-title":"Arch Gynecol Obstet"},{"key":"10.1111\/aji.12298-BIB0040|aji12298-cit-0040","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cca.2013.09.050","article-title":"Severe preeclampsia: are hemostatic and inflammatory parameters associated?","volume":"427","author":"Pinheiro","year":"2014","journal-title":"Clin Chim Acta"},{"key":"10.1111\/aji.12298-BIB0041|aji12298-cit-0041","doi-asserted-by":"crossref","first-page":"CR506","DOI":"10.12659\/MSM.883271","article-title":"Leptin and interferon-gamma as possible predictors of cesarean section among women with hypertensive disorders of pregnancy","volume":"18","author":"Rytlewski","year":"2012","journal-title":"Med Sci Monit"},{"key":"10.1111\/aji.12298-BIB0042|aji12298-cit-0042","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1600-0897.2012.01158.x","article-title":"Biomarkers of coagulation, inflammation, and angiogenesis are independently associated with preeclampsia","volume":"68","author":"Boij","year":"2012","journal-title":"Am J Reprod Immunol"},{"key":"10.1111\/aji.12298-BIB0043|aji12298-cit-0043","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1600-0897.2010.00903.x","article-title":"Role of endothelin and inflammatory cytokines in pre-eclampsia - a pilot North Indian study","volume":"65","author":"Sharma","year":"2011","journal-title":"Am J Reprod Immunol"},{"key":"10.1111\/aji.12298-BIB0044|aji12298-cit-0044","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1600-0897.2009.00763.x","article-title":"Imbalance of T-cell transcription factors contributes to the Th1 type immunity predominant in pre-eclampsia","volume":"63","author":"Jianjun","year":"2010","journal-title":"Am J Reprod Immunol"},{"key":"10.1111\/aji.12298-BIB0045|aji12298-cit-0045","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1046\/j.1365-2249.1999.00997.x","article-title":"Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsia","volume":"117","author":"Saito","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"10.1111\/aji.12298-BIB0046|aji12298-cit-0046","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jim.2008.04.006","article-title":"Effects of blood sample handling procedures on measurable inflammatory markers in plasma, serum and dried blood spot samples","volume":"336","author":"Skogstrand","year":"2008","journal-title":"J Immunol Methods"},{"key":"10.1111\/aji.12298-BIB0047|aji12298-cit-0047","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/eurheartj\/ehr441","article-title":"Plant sterols and cardiovascular disease: a systematic review and meta-analysis","volume":"33","author":"Genser","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1111\/aji.12298-BIB0048|aji12298-cit-0048","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/humupd\/dmq027","article-title":"Insulin-like growth factor binding protein-1 in PCOS: a systematic review and meta-analysis","volume":"17","author":"Kelly","year":"2011","journal-title":"Hum Reprod Update"},{"key":"10.1111\/aji.12298-BIB0049|aji12298-cit-0049","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/HJH.0b013e32835b0556","article-title":"C-reactive protein and later preeclampsia: systematic review and meta-analysis taking into account the weight status","volume":"31","author":"Rebelo","year":"2013","journal-title":"J Hypertens"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faji.12298","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/aji.12298\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T07:46:59Z","timestamp":1625298419000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.12298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,25]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,11]]}},"URL":"https:\/\/doi.org\/10.1111\/aji.12298","relation":{},"ISSN":["1046-7408"],"issn-type":[{"value":"1046-7408","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7,25]]}}}