{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:14:19Z","timestamp":1791231259705,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T00:00:00Z","timestamp":1411516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:label\/><jats:p>Human plasminogen activator inhibitor\u20101 (<jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content>\u20101) is closely related to embryonic development and pregnancy success. The association between <jats:italic><jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content>\u20101<\/jats:italic> gene polymorphisms (<jats:italic><jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content>\u20101<\/jats:italic>\u2010844G\/A and <jats:italic><jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content>\u20101<\/jats:italic>\u2010675G\/A) and the risk of recurrent pregnancy loss (<jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>) is controversial. Therefore, we perform this review to clarify the association between <jats:italic><jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content>\u20101<\/jats:italic> gene polymorphisms and <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content> risk. We performed a systematic search for studies that described the effect of <jats:italic><jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content>\u20101<\/jats:italic> polymorphisms on <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content> risk. The odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s) with corresponding 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s) were considered under recessive genetic models. Furthermore, we conducted a subgroup analysis based on the studies' geographic regions of origin. Data were analyzed using Stata 11.2 software. Eighteen studies were included, and a high degree of statistical heterogeneity existed among the studies. In this study, we found a significant association between the <jats:italic><jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content>\u20101<\/jats:italic>\u2010675G\/A polymorphism and the risk of <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content> under the recessive model (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.70, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.21\u20132.38). However, no significant association between the <jats:italic><jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content>\u20101<\/jats:italic>\u2010844G\/A polymorphism and <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content> was noted. <jats:italic><jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content>\u20101<\/jats:italic>\u2010675G\/A (4G\/5G) polymorphisms play a potential role in <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>. The screening of <jats:italic><jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content>\u20101<\/jats:italic> (4G\/5G) gene mutations should be included during an <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content> diagnostic workup, and patients should be treated using anticoagulant therapy during pregnancy if necessary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12321","type":"journal-article","created":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T05:33:53Z","timestamp":1411536833000},"page":"292-300","source":"Crossref","is-referenced-by-count":30,"title":["Association between Plasminogen Activator Inhibitor\u20101 Gene Polymorphisms and Recurrent Pregnancy Loss: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"73","author":[{"given":"Hui","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health Shandong University Jinan 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