{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:58:13Z","timestamp":1790614693269,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T00:00:00Z","timestamp":1411948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"French Ministry for Health (PHRC interregional 2006)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Problem<\/jats:title>To evaluate the inflammatory pattern in maternal circulation from women with preterm premature rupture of membranes (PPROM<\/jats:styled-content>) considering the occurrence of histologically confirmed chorioamnionitis (HCA<\/jats:styled-content>).<\/jats:p><\/jats:sec>Method of study<\/jats:title>A prospective study was conducted in 121 women with PPROM<\/jats:styled-content> between 24 and 34\u00a0+\u00a00\u00a0weeks of gestation. Association between white blood cells (WBC<\/jats:styled-content>) count, plasma CRP<\/jats:styled-content>, IL<\/jats:styled-content>\u20106, MCP<\/jats:styled-content>\u20101 and IP<\/jats:styled-content>\u201010 levels, and HCA<\/jats:styled-content> was assessed.<\/jats:p><\/jats:sec>Results<\/jats:title>The rate of HCA<\/jats:styled-content> was 44.7% (54\/121). During the 5\u00a0days preceding delivery, median CRP<\/jats:styled-content>, WBC<\/jats:styled-content>, and IL<\/jats:styled-content>\u20106 levels were significantly higher in the HCA<\/jats:styled-content> than in no\u2010HCA<\/jats:styled-content> group (P<\/jats:italic>\u00a0<\u00a00.001). Variations in IL<\/jats:styled-content>\u20106, IP<\/jats:styled-content>\u201010 levels, during the 24\u201372\u00a0hr before delivery, were predictors of the occurrence of HCA<\/jats:styled-content>, but the diagnostic accuracy was low [Receiver Operating Characterictic (ROC<\/jats:styled-content>) curve, area under the curve (AUC<\/jats:styled-content>)\u00a0=\u00a00.56].<\/jats:p><\/jats:sec>Conclusion<\/jats:title>An increase in IL<\/jats:styled-content>\u20106, CRP<\/jats:styled-content>, IP<\/jats:styled-content>\u201010 maternal plasma levels was confirmed in PPROM<\/jats:styled-content> women with HCA<\/jats:styled-content>. Longitudinal follow\u2010up of these markers did not add valuable information regarding HCA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12323","type":"journal-article","created":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T05:13:18Z","timestamp":1411967598000},"page":"79-90","source":"Crossref","is-referenced-by-count":31,"title":["Changes in Maternal Blood Inflammatory Markers As a Predictor Of Chorioamnionitis: A Prospective Multicenter Study"],"prefix":"10.1111","volume":"73","author":[{"given":"Isabelle","family":"Le Ray","sequence":"first","affiliation":[{"name":"Centre d'Investigations Cliniques 1432 (INSERM CIC 1432) CHU Dijon Dijon Cedex France"},{"name":"Universit\u00e9 de Bourgogne Dijon France"},{"name":"R\u00e9seau National Gyn\u00e9cologie et Obst\u00e9trique des CIC de l'INSERM GO\u2010CIC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Mace","sequence":"additional","affiliation":[{"name":"R\u00e9seau National Gyn\u00e9cologie et Obst\u00e9trique des CIC de l'INSERM GO\u2010CIC"},{"name":"Service de Gyn\u00e9cologie et d'Obst\u00e9trique CHU de Dijon Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mourad","family":"Sediki","sequence":"additional","affiliation":[{"name":"Centre d'Investigations Cliniques 1432 (INSERM CIC 1432) CHU Dijon Dijon Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Lirussi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bourgogne Dijon France"},{"name":"Laboratoire de Pharmacologie\u2010Toxicologie CHU de Dijon Dijon France"},{"name":"Centre de Recherche Lipides Nutrition Cancer U866 INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Riethmuller","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie et d'Obst\u00e9trique CHU Jean Minjoz Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Lentz","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie et d'Obst\u00e9trique CH de Ch\u00e2lon\u2010Sur\u2010Sa\u00f4ne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev","family":"Ramanah","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie et d'Obst\u00e9trique CHU Jean Minjoz Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toufic","family":"Hoyek","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie et d'Obst\u00e9trique CH d'Auxerre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Spagnolo","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie et d'Obst\u00e9trique CH de M\u00e2con"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Laurent","sequence":"additional","affiliation":[{"name":"Service d'Anatomo\u2010Pathologie CHU de Dijon Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Goirand","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bourgogne Dijon France"},{"name":"Laboratoire de Pharmacologie\u2010Toxicologie CHU de Dijon Dijon France"},{"name":"Centre de Recherche Lipides Nutrition Cancer U866 INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Sagot","sequence":"additional","affiliation":[{"name":"R\u00e9seau National Gyn\u00e9cologie et Obst\u00e9trique des CIC de l'INSERM GO\u2010CIC"},{"name":"Service de Gyn\u00e9cologie et d'Obst\u00e9trique CHU de Dijon Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bardou","sequence":"additional","affiliation":[{"name":"Centre d'Investigations Cliniques 1432 (INSERM CIC 1432) CHU Dijon Dijon Cedex France"},{"name":"Universit\u00e9 de Bourgogne Dijon France"},{"name":"R\u00e9seau National Gyn\u00e9cologie et Obst\u00e9trique des CIC de l'INSERM GO\u2010CIC"},{"name":"Centre de Recherche Lipides Nutrition Cancer U866 INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2005.03.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-0005(03)00016-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00582.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-999527"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1333408"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)90686-3"},{"key":"e_1_2_8_8_1","first-page":"1","article-title":"Maternal plasma levels of interleukin\u20106, C\u2010reactive protein, vitamins C, E and A, 8\u2010isoprostane and oxidative status in women with preterm premature rupture of membranes","volume":"22","author":"Ilhan N","year":"2014","journal-title":"J Matern Fetal Neonatal Med"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00500.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb11086.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.10.014"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(90)90139-R"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079941"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/412831"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.784741"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463201202500420"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043677"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199606000-00008"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12073"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.638952"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2011.01084.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02577.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2005.003"},{"key":"e_1_2_8_24_1","first-page":"857","article-title":"Umbilical cord blood concentrations of IL\u20106, IL\u20108, and MMP\u20108 in pregnancy complicated by preterm premature rupture of the membranes and histological chorioamnionitis","volume":"31","author":"Andrys C","year":"2010","journal-title":"Neuro Endocrinol Lett"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2004.09.012"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2012-0034"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2629-3"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085277"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.08.028"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.594119"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2271-0"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.4.462"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01385.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.09.017"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000250474.35369.12"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181cb5c0e"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-003-7070-y"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2012-201124"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-0005(98)80004-9"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90014-A"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2005.11.049"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12028"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.10.882"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.11.047"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719111432869"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgyn.2012.12.012"},{"key":"e_1_2_8_47_1","first-page":"e271","article-title":"Management of late\u2010preterm premature rupture of membranes: the PPROMEXIL\u20102 trial","volume":"207","author":"Ham DP","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001208"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2012.160"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2010.00889.x"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12265"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2013.08.017"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.08.031"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2009.106"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.02.003"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.03.027"},{"key":"e_1_2_8_57_1","first-page":"1","article-title":"Cervical and vaginal fluid soluble Toll\u2010like receptor 2 in pregnancies complicated by preterm prelabor rupture of membranes","volume":"12","author":"Kacerovsky M","year":"2014","journal-title":"J Matern Fetal Neonatal Med"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faji.12323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faji.12323","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.12323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T06:05:07Z","timestamp":1696485907000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.12323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,29]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/aji.12323"],"URL":"https:\/\/doi.org\/10.1111\/aji.12323","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,29]]}}}