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We have reported decidual leukocyte infiltration prior to and during labor; the regulators of these inflammatory processes are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Choriodecidua <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> obtained after term labor or elective cesarean delivery was applied to Affymetrix GeneChips. Pathway analysis and gene validation were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Extensive inflammatory activation was identified in choriodecidua following labor, predominantly upregulation of genes regulating leukocyte trafficking and cytokine signalling. Genes governing cell fate, tissue remodelling, and translation were also altered. Upregulation of candidate genes (<jats:italic><jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>1<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>4<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>44<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>4<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">SOCS<\/jats:styled-content>3<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>2A, and <jats:styled-content style=\"fixed-case\">IDO<\/jats:styled-content>)<\/jats:italic> was confirmed. <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u03baB, <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>1&amp;3, <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1, and mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u201021, mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u201046, mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010141, and mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010200 were predicted upstream regulators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study confirms inflammatory processes are major players in labor events in choriodecidua, as in other gestational tissues. Suppressing uterine inflammation is likely to be critical for arresting premature labor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12328","type":"journal-article","created":{"date-parts":[[2014,10,4]],"date-time":"2014-10-04T04:48:02Z","timestamp":1412398082000},"page":"36-55","source":"Crossref","is-referenced-by-count":48,"title":["Transcriptomic Profiling of Human Choriodecidua During Term Labor: Inflammation as a Key Driver of Labor"],"prefix":"10.1111","volume":"73","author":[{"given":"Gillian L.","family":"Stephen","sequence":"first","affiliation":[{"name":"Maternal and Fetal Health Research Centre University of Manchester Manchester UK"},{"name":"St. Mary's Hospital Central Manchester University Hospitals NHS Foundation Trust Manchester Academic Health Science Centre Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Lui","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Health Research Centre University of Manchester Manchester UK"},{"name":"St. Mary's Hospital Central Manchester University Hospitals NHS Foundation Trust Manchester Academic Health Science Centre Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Health Research Centre University of Manchester Manchester UK"},{"name":"St. Mary's Hospital Central Manchester University Hospitals NHS Foundation Trust Manchester Academic Health Science Centre Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare L.","family":"Tower","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Health Research Centre University of Manchester Manchester UK"},{"name":"St. Mary's Hospital Central Manchester University Hospitals NHS Foundation Trust Manchester Academic Health Science Centre Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda K.","family":"Harris","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Health Research Centre University of Manchester Manchester UK"},{"name":"St. Mary's Hospital Central Manchester University Hospitals NHS Foundation Trust Manchester Academic Health Science Centre Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Stevens","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Health Research Centre University of Manchester Manchester UK"},{"name":"Paediatrics and Child Health Centre University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Jones","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Health Research Centre University of Manchester Manchester UK"},{"name":"St. Mary's Hospital Central Manchester University Hospitals NHS Foundation Trust Manchester Academic Health Science Centre Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,4]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Confidential Enquiry on Maternal and Child HealthPerinatal Mortality 20052007."},{"key":"e_1_2_6_3_1","unstructured":"WHO: World Health Organisation Preterm birth fact sheet No 363. 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