{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:58:02Z","timestamp":1781305082532,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T00:00:00Z","timestamp":1414108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>An association between serum prolactin (<jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content>) and peripheral blood natural killer (<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>) cells has been described in healthy women. We explored for the first time the <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> response to the thyrotrophin\u2010releasing hormone (<jats:styled-content style=\"fixed-case\">TRH<\/jats:styled-content>) test and the association between <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells in women with reproductive failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 130 women [31 primary infertility, 69 recurrent spontaneous abortion (RSA), and 30 fertile women] were evaluated by a TRH test to analyze the following: basal PRL (<jats:styled-content style=\"fixed-case\">bPRL<\/jats:styled-content>), peak\u2010time PRL, PRL absolute and relative increase, decline\u2010time PRL. Hyperprolactinaemia (HPRL) was defined as <jats:styled-content style=\"fixed-case\">bPRL<\/jats:styled-content> \u226515\u00a0ng\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>. NK cells were characterized by immunophenotyping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly higher <jats:styled-content style=\"fixed-case\">bPRL<\/jats:styled-content> levels were found in the infertile women than in controls. Both the infertile and the RSA women showed significantly elevated NK levels. <jats:styled-content style=\"fixed-case\">bPRL<\/jats:styled-content> levels correlated with NK cells in HPRL\u2010infertile women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with HPRL, an association between NK cell and <jats:styled-content style=\"fixed-case\">bPRL<\/jats:styled-content> results. The dynamic test in the infertile women would help in the management of the pregnancy impairment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12335","type":"journal-article","created":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T04:40:50Z","timestamp":1414125650000},"page":"56-65","source":"Crossref","is-referenced-by-count":33,"title":["Prolactin and Natural Killer Cells: Evaluating the Neuroendocrine\u2010immune Axis in Women with Primary Infertility and Recurrent Spontaneous Abortion"],"prefix":"10.1111","volume":"73","author":[{"given":"Paola","family":"Triggianese","sequence":"first","affiliation":[{"name":"Department of \u2018Medicina dei Sistemi\u2019 Rheumatology, Allergology and Clinical Immunology University of Rome Tor Vergata Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Perricone","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Interna e Specialit\u00e0 Mediche Reumatologia Sapienza 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