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The recent Ebola outbreak and other viral epidemics and pandemics show how pregnant women suffer worse outcomes (such as preterm labor\u00a0and adverse fetal outcomes) than the general population and non\u2010pregnant women. New knowledge about the ways the maternal\u2013fetal interface and placenta interact with the maternal immune system may explain these findings. Once thought to be \u2018immunosuppressed\u2019, the pregnant woman actually undergoes an immunological transformation, where the immune system is necessary to promote and support the pregnancy and growing fetus. When this protection is breached, as in a viral infection, this security is weakened and infection with other microorganisms can then propagate and lead to outcomes, such as preterm labor. In this manuscript, we review the major viral infections relevant to pregnancy and offer potential mechanisms for the associated adverse pregnancy outcomes.<\/jats:p>","DOI":"10.1111\/aji.12355","type":"journal-article","created":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T00:48:12Z","timestamp":1421110092000},"page":"199-213","source":"Crossref","is-referenced-by-count":420,"title":["Viral Infections During Pregnancy"],"prefix":"10.1111","volume":"73","author":[{"given":"Michelle","family":"Silasi","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences Yale University School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Cardenas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences Yale University School of Medicine New Haven CT 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