{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:00:37Z","timestamp":1758981637882,"version":"3.37.3"},"reference-count":73,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,6,13]],"date-time":"2015-06-13T00:00:00Z","timestamp":1434153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>We have previously determined that long non\u2010coding <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s (lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s) are differentially expressed in preterm premature rupture of membranes (<jats:styled-content style=\"fixed-case\">PPROM<\/jats:styled-content>) and hypothesized that the collagenolysis ubiquitin\u2013proteasome system may be activated by infection and inflammation. However, direct evidence of the involvement of lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s in transcriptional and posttranscriptional regulation of the infection\u2010triggered alteration of collagen is lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>A previously developed mouse model with <jats:styled-content style=\"fixed-case\">MHV<\/jats:styled-content>68 viral infection was assessed to determine whether viral infection may induce differential expression of lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s in mouse placentas and amniotic sacs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Differential expression of lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s that are associated with collagen was found in <jats:styled-content style=\"fixed-case\">HMV<\/jats:styled-content>68 viral\u2010infected, compared to non\u2010infected, mouse placentas and amniotic sacs. Differential expression of messenger <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s (<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>s) of collagen was also documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data demonstrate, for the first time, that viral infection may induce the differential expression of lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s that are associated with collagen. Based on this finding, we propose that lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> may have involved in regulating of infection\u2010induced collagen transcription.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12406","type":"journal-article","created":{"date-parts":[[2015,6,13]],"date-time":"2015-06-13T06:11:07Z","timestamp":1434175867000},"page":"237-257","source":"Crossref","is-referenced-by-count":4,"title":["Viral Infection\u2010Induced Differential Expression of Lnc<scp>RNA<\/scp>s Associated with Collagen in Mouse Placentas and Amniotic Sacs"],"prefix":"10.1111","volume":"74","author":[{"given":"Jing","family":"Pan","sequence":"first","affiliation":[{"name":"Center of Translational Medicine for Maternal and Children's Health Lianyungang Maternal and Children's Hospital Lianyungang Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gil","family":"Mor","sequence":"additional","affiliation":[{"name":"Department of Obstetrics 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