{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:23:22Z","timestamp":1792211002441,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T00:00:00Z","timestamp":1451520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Sterile intra\u2010amniotic inflammation is associated with spontaneous preterm labor. Alarmins are proposed to mediate this inflammatory process. The aim of this study was to determine whether intra\u2010amniotic administration of an alarmin, <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1, could induce preterm labor\/birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>Pregnant B6 mice were intra\u2010amniotically or intraperitoneally injected with <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1 or <jats:styled-content style=\"fixed-case\">PBS<\/jats:styled-content> (control). Following injection, the gestational age and the rates of preterm birth and pup mortality were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intra\u2010amniotic injection of <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1 led to preterm labor\/birth [<jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1 57% (4\/7) versus <jats:styled-content style=\"fixed-case\">PBS<\/jats:styled-content> 0% (0\/6); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.049) and a high rate of pup mortality at week 1 [<jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1 60.9\u00a0\u00b1\u00a011.7% (25\/41) versus <jats:styled-content style=\"fixed-case\">PBS<\/jats:styled-content> 28.9\u00a0\u00b1\u00a012.6% (11\/38); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Intraperitoneal injection of HMGB1 did not induce preterm labor\/birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intra\u2010amniotic administration of <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>1 induces preterm labor\/birth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12443","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T20:16:46Z","timestamp":1452025006000},"page":"3-7","source":"Crossref","is-referenced-by-count":128,"title":["Intra\u2010Amniotic Administration of HMGB1 Induces Spontaneous Preterm Labor and Birth"],"prefix":"10.1111","volume":"75","author":[{"given":"Nardhy","family":"Gomez\u2010Lopez","sequence":"first","affiliation":[{"name":"Perinatology Research Branch Program for Perinatal Research and Obstetrics Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development NICHD\/NIH\/DHHS Bethesda, MD, and Detroit MI USA"},{"name":"Department of Obstetrics and Gynecology Wayne State University School of Medicine Detroit MI USA"},{"name":"Department of Immunology and Microbiology Wayne State University School of Medicine Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Romero","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch Program for Perinatal Research and Obstetrics Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development NICHD\/NIH\/DHHS Bethesda, MD, and Detroit MI USA"},{"name":"Department of Obstetrics and Gynecology University of Michigan Ann Arbor MI USA"},{"name":"Department of Epidemiology and Biostatistics Michigan State University East Lansing MI USA"},{"name":"Center for Molecular Medicine and Genetics Wayne State University Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olesya","family":"Plazyo","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch Program for Perinatal Research and Obstetrics Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development NICHD\/NIH\/DHHS Bethesda, MD, and Detroit MI USA"},{"name":"Department of Obstetrics and Gynecology Wayne State University School of Medicine Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Panaitescu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Neonatology Division Wayne State University School of Medicine Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E.","family":"Furcron","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch Program for Perinatal Research and Obstetrics Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development NICHD\/NIH\/DHHS Bethesda, MD, and Detroit MI USA"},{"name":"Department of Obstetrics and Gynecology Wayne State University School of Medicine Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Miller","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch Program for Perinatal Research and Obstetrics Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development NICHD\/NIH\/DHHS Bethesda, MD, and Detroit MI USA"},{"name":"Department of Obstetrics and Gynecology Wayne State University School of Medicine Detroit MI USA"},{"name":"Department of Immunology and Microbiology Wayne State University School of Medicine Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Roumayah","sequence":"additional","affiliation":[{"name":"Perinatology Research 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