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Overproduction of reactive oxygen species and reactive nitrogen species can destroy normal placental functions. Therefore, the feto\u2010placental unit generates abundant antioxidants to keep\n                    <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                    under control. Properly controlled oxidative species have been proven to serve as indispensable cellular signal messengers by regulating gene expression and downstream cellular activities.\n                    <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                    also plays an important immunoregulatory role during pregnancy. Oxidative disorder and immune disturbances are associated with adverse pregnancy outcomes such as spontaneous abortion, preeclampsia and intrauterine growth restriction. In this review, we introduce recent studies revealing basal functions and regulatory roles of placental\n                    <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                    in metabolism and immunity. The relationships between\n                    <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                    \u2010 and pregnancy\u2010related disorders are also discussed.\n                  <\/jats:p>","DOI":"10.1111\/aji.12454","type":"journal-article","created":{"date-parts":[[2015,11,21]],"date-time":"2015-11-21T02:23:20Z","timestamp":1448072600000},"page":"258-271","source":"Crossref","is-referenced-by-count":143,"title":["Oxidative Stress: Placenta Function and Dysfunction"],"prefix":"10.1111","volume":"76","author":[{"given":"Fan","family":"Wu","sequence":"first","affiliation":[{"name":"Institute of Embryo\u2010Fetal Original Adult Disease the International Peace Maternity &amp; Child Health Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010Ju","family":"Tian","sequence":"additional","affiliation":[{"name":"Institute of Embryo\u2010Fetal Original Adult 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