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Glycodelin\u2010A is a glycoprotein abundant in the decidua during early pregnancy. It plays an important role in placental development and fetomaternal defense. Glycodelin\u2010A interacts by its unique carbohydrate side chains with the cell surface of various cell types in the human fetomaternal interface, particularly the trophoblasts and the immune cells, and modulates their functions and differentiation to permit successful pregnancy. Abnormal levels of glycodelin\u2010A in the endometrium, uterine flushings, and\/or maternal serum correlate with unexplained infertility, early pregnancy loss, and recurrent miscarriage. This review integrates recent studies on the role of glycodelin\u2010A in placental development and fetomaternal tolerance in early pregnancy.<\/jats:p>","DOI":"10.1111\/aji.12471","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T09:22:09Z","timestamp":1452590529000},"page":"290-297","source":"Crossref","is-referenced-by-count":57,"title":["The Pleiotropic Effect of Glycodelin\u2010A in Early Pregnancy"],"prefix":"10.1111","volume":"75","author":[{"given":"Cheuk\u2010Lun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology LKS Faculty of Medicine The University of Hong Kong Hong Kong Hong Kong"},{"name":"Centre for Reproduction, Development and Growth LKS Faculty of Medicine The University of Hong Kong Hong Kong Hong Kong"},{"name":"Shenzhen Key Laboratory of Fertility Regulation Department of Obstetrics and Gynecology The University of Hong Kong\u2010Shenzhen Hospital Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin K. 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