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Although they account for a small portion of the total human circulating T\u2010cell pool, their associations with other immune cells and their potential regulatory roles in related diseases have been explored but still require further investigation. \u03b3\u03b4T cells which are <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content>\u2010unrestricted innate\u2010like lymphocytes with more unique antigen receptors than \u03b1\u03b2T cells and B cells are considered to bridge innate and adaptive immunity. They have <jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content> functions and initiate adaptive immunity. Due to their distribution in specific tissues, secretion of Th1\u2010, Th2\u2010, and Th17\u2010type cytokines, and other characteristics, they are involved in a variety of physiology and pathology processes. They are barometers in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection. However, different \u03b3\u03b4T cell subsets play opposing roles in <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> infections, autoimmune diseases, and several types of tumors. Moreover, decidual \u03b3\u03b4T cells have protective roles during pregnancies by synthesizing several cytokines. 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