{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:41:21Z","timestamp":1761597681511},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T00:00:00Z","timestamp":1455840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370767"],"award-info":[{"award-number":["81370767"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Spontaneous abortion is a poorly understood phenomenon, although fetomaternal intolerance is known to play an important role in its pathogenesis. The tyrosine\u2010specific phosphotransferase Fyn has been reported as a significant regulator in immune response. However, its role in fetomaternal immune tolerance and contribution to spontaneous abortion remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods of study<\/jats:title><jats:p>Fyn expression was evaluated at the fetomaternal interface of normal pregnant and abortion\u2010prone mice, as well as in decidual tissue obtained from normal human pregnancies and idiopathic miscarriages. A Fyn inhibitor was administrated into the <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010induced abortion mice to investigate the variation of embryo resorption and local immunity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fyn expression fluctuated with the progress of normal pregnancy and was elevated in abortion\u2010prone mice and patients with recurrent spontaneous abortion. The Fyn inhibitor reversed <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010induced embryo absorption and aberrant inflammatory status including redundant expression of <jats:styled-content style=\"fixed-case\">IRF<\/jats:styled-content>4 and increased proportion of Th17 cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fyn is confirmed as a negative regulator in fetomaternal immune tolerance, through promoting Th17 cell expansion and proinflammatory factors expression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12498","type":"journal-article","created":{"date-parts":[[2016,2,20]],"date-time":"2016-02-20T14:27:29Z","timestamp":1455978449000},"page":"569-579","source":"Crossref","is-referenced-by-count":7,"title":["Fyn Plays a Pivotal Role in Fetomaternal Tolerance Through Regulation of Th17 Cells"],"prefix":"10.1111","volume":"75","author":[{"given":"Qian","family":"Liu","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu\u2010ju","family":"Tian","sequence":"additional","affiliation":[{"name":"Institute of Embryo\u2010Fetal Original Adult Disease the International Peace Maternity &amp; Child Health Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing\u2010zhen","family":"Xie","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine 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