{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:31:05Z","timestamp":1791549065934,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T00:00:00Z","timestamp":1457308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CHR"},{"name":"Foundation for Reproductive Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>To determine in women with recurrent pregnancy loss (<jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>) and\/or implantation failure (<jats:styled-content style=\"fixed-case\">RIF<\/jats:styled-content>) the prevalence of chronic endometritis (<jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>), systemic inflammation and autoimmunity, and whether they relate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>This retrospective study examined inflammatory (adiponectin, <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>, leptin, and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>6) and autoimmune (total immunoglobulins, <jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content>, thyroid antibodies, antiphospholipid antibodies) markers in a group of 55 women with <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">RIF<\/jats:styled-content>. A diagnosis of <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> was reached by endometrial biopsy, demonstrating <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>138\u2010positive plasma cells on histology. The prevalence of markers of systemic inflammation and autoimmunity was compared between women with and without <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among all <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">RIF<\/jats:styled-content> patients, 32.7% demonstrated at least one positive inflammatory marker, 61.8% at least one autoimmune marker, and 45.5% <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>. Moreover, <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> patients did not differ in systematic inflammatory or autoimmune profiles from those without <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Endometritis and elevated inflammatory and autoimmune markers are common in women with <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">RIF<\/jats:styled-content>, but endometritis cannot be predicted based on either peripheral inflammatory or autoimmune markers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12508","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T04:54:42Z","timestamp":1457412882000},"page":"672-677","source":"Crossref","is-referenced-by-count":107,"title":["Systemic Inflammation and Autoimmunity in Women with Chronic 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