{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:16:36Z","timestamp":1784733396023,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Allogenic lymphocyte immunotherapy (<jats:styled-content style=\"fixed-case\">LIT<\/jats:styled-content>) as a treatment for unexplained recurrent spontaneous abortion (<jats:styled-content style=\"fixed-case\">URSA<\/jats:styled-content>) is still controversial due to the lack of enough controls to evaluate its effectiveness. Eighteen randomized, placebo\u2010controlled trials with <jats:styled-content style=\"fixed-case\">LIT<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">URSA<\/jats:styled-content> were included in the meta\u2010analysis. Live birth rates for each group were extracted, and the overall odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) for <jats:styled-content style=\"fixed-case\">LIT<\/jats:styled-content> was calculated. The success rate of treatment group was significantly higher (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.74, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.07 ~ 4.57). <jats:styled-content style=\"fixed-case\">LIT<\/jats:styled-content> performed before and during pregnancy had dramatically improved the live birth rate in women with <jats:styled-content style=\"fixed-case\">URSA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.67, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.70 ~ 5.90). The overall <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> was 5.25 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 4.16 ~ 6.64), which supports a low dose of lymphocytes for treating <jats:styled-content style=\"fixed-case\">URSA<\/jats:styled-content>. Our results indicate that <jats:styled-content style=\"fixed-case\">LIT<\/jats:styled-content> provides a significantly beneficial effect over placebo for <jats:styled-content style=\"fixed-case\">URSA<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">LIT<\/jats:styled-content> given before and during pregnancy is superior to <jats:styled-content style=\"fixed-case\">LIT<\/jats:styled-content> given only before pregnancy, and the lower doses per treatment (less than 100 \u00d7 10<jats:sup>6<\/jats:sup> lymphocytes or 100 <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> peripheral blood) achieved a better outcome.<\/jats:p>","DOI":"10.1111\/aji.12511","type":"journal-article","created":{"date-parts":[[2016,4,23]],"date-time":"2016-04-23T07:09:34Z","timestamp":1461395374000},"page":"443-453","source":"Crossref","is-referenced-by-count":68,"title":["Allogenic Lymphocyte Immunotherapy for Unexplained Recurrent Spontaneous Abortion: A Meta\u2010Analysis"],"prefix":"10.1111","volume":"76","author":[{"given":"Zhilan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongfei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ren Ji Hospital School of Medicine Shanghai Jiao 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