{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:46Z","timestamp":1787702446258,"version":"build-2784847793"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T00:00:00Z","timestamp":1462406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n                    <jats:title>Problem<\/jats:title>\n                    <jats:p>\n                      Cyclosporin A (\n                      <jats:styled-content style=\"fixed-case\">CYS<\/jats:styled-content>\n                      A) is an immunosuppressant agent administered in autoimmune diseases, and its use during pregnancy and lactation is a debated topic.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method of study<\/jats:title>\n                    <jats:p>\n                      The demographic characteristics, the activity of the underlying disease, and the onset of fetal\u2013maternal complications have been investigated in 21 consecutive patients (2\n                      <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n                      , 14\n                      <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>\n                      , 2\n                      <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n                      , 1 SjS, 1\n                      <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                      , 1 Churg\u2013Strauss vasculitis), treated with\n                      <jats:styled-content style=\"fixed-case\">CYS<\/jats:styled-content>\n                      A throughout 29 gestations. A subanalysis of the\n                      <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>\n                      group was performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We recorded a live birth rate of 86.2%. The median gestational age at birth was 38.2 weeks. The prevalence of maternal\u2013fetal complications showed no differences with general population. Disease flares appeared in 4% of patients during gestation and in 12% during puerperium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      We found no evidence justifying the suspension of\n                      <jats:styled-content style=\"fixed-case\">CYS<\/jats:styled-content>\n                      A when a pregnancy occurs. The drug does not appear to promote maternal\u2013fetal complications and should be continued in patients who benefit from therapy. Data regarding breast\u2010feeding during therapy are still scarce, but no evidence of toxicity has emerged.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.12514","type":"journal-article","created":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T04:36:41Z","timestamp":1462423001000},"page":"654-660","source":"Crossref","is-referenced-by-count":30,"title":["The Efficacy and Safety of Cyclosporin A in Pregnant Patients with Systemic Autoimmune Diseases"],"prefix":"10.1111","volume":"75","author":[{"given":"Rossella","family":"Reggia","sequence":"first","affiliation":[{"name":"Rheumatology and Clinical Immunology Spedali Civili and University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Bazzani","sequence":"additional","affiliation":[{"name":"Rheumatology and Clinical Immunology Spedali Civili and University of Brescia Brescia 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