{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:15:23Z","timestamp":1789370123221,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,12]],"date-time":"2016-06-12T00:00:00Z","timestamp":1465689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Nearly 65\u00a0years have passed since <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>eter <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edawar posed the following question: \u201cHow does the pregnant mother contrive to nourish within itself, for many weeks or months, a fetus that is an antigenically foreign body.\u201d Now, understanding of reproductive immunology has demonstrated that the <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> antigens in the placenta are non\u2010classical and do not induce rejection. In the placenta and in tumors, 50% or more of the cells are cells of the immune system and were once thought to be primed and ready for killing tumors or the \u201cfetal transplant\u201d but these cells are not potential killers but abet the growth of either the tumor or the placenta. We believe that these cells are there to create an environment, which enhances either placental or tumor growth. By examining the similarities of the placenta's and tumor's immune cells, novel mechanisms to cause tumors to be eliminated can be devised.<\/jats:p>","DOI":"10.1111\/aji.12524","type":"journal-article","created":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T04:23:29Z","timestamp":1465791809000},"page":"3-7","source":"Crossref","is-referenced-by-count":32,"title":["Pregnancy is a model for tumors, not transplantation"],"prefix":"10.1111","volume":"76","author":[{"given":"Kenneth D.","family":"Beaman","sequence":"first","affiliation":[{"name":"Clinical Immunology Laboratory  Department of Microbiology and Immunology Rosalind Franklin University of Medicine and Science  North Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukesh K.","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"Clinical Immunology Laboratory  Department of Microbiology and Immunology Rosalind Franklin University of Medicine and Science  North Chicago IL 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