{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:10:33Z","timestamp":1768561833034,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T00:00:00Z","timestamp":1469577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chinese 973","award":["2012CB517702"],"award-info":[{"award-number":["2012CB517702"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>To investigate the expression of complement activation factors in plasma of patients with early\/late\u2010onset severe pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2013control study was performed. The study group consisted of 30 cases of early\u2010onset severe pre\u2010eclampsia (<jats:styled-content style=\"fixed-case\">EOSPE<\/jats:styled-content>) and 30 cases of late\u2010onset severe pre\u2010eclampsia (<jats:styled-content style=\"fixed-case\">LOSPE<\/jats:styled-content>). Thirty cases were selected as the early\u2010onset control group (E\u2010control) and 30 as the late\u2010onset control group (L\u2010control). <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> was used to test C1q, C4d, <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>, Bb, C3a, C5a, and <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> in the maternal peripheral circulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The complement activation factors Bb, C3a, C5a, and <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> were increased significantly in <jats:styled-content style=\"fixed-case\">EOSPE<\/jats:styled-content> (all <jats:italic>P<\/jats:italic>&lt;.01) and <jats:styled-content style=\"fixed-case\">LOSPE<\/jats:styled-content> (<jats:italic>P<\/jats:italic> value: .027, &lt;.001, .001, and &lt;.001, respectively) compared with E\/L\u2010control. C1q and C4d were increased significantly in <jats:styled-content style=\"fixed-case\">LOSPE<\/jats:styled-content> (<jats:italic>P<\/jats:italic> value: .003 and .014, respectively) compared with L\u2010control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Abnormal activation of the complement system exists in the maternal circulation of patients with early\u2010 and late\u2010onset severe pre\u2010eclampsia. In patients complicated with <jats:styled-content style=\"fixed-case\">LOSPE<\/jats:styled-content>, the complement system was activated through both the classical and alternative pathways, while in <jats:styled-content style=\"fixed-case\">EOSPE<\/jats:styled-content>, the complement system was activated mainly through the alternative pathway.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12541","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T11:06:20Z","timestamp":1469617580000},"page":"205-211","source":"Crossref","is-referenced-by-count":37,"title":["Expression of the complement system's activation factors in plasma of patients with early\/late\u2010onset severe pre\u2010eclampsia"],"prefix":"10.1111","volume":"76","author":[{"given":"Yingdong","family":"He","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingning","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Song","sequence":"additional","affiliation":[{"name":"Renal Division Department of Medicine Peking University First Hospital Peking University Institute of Nephrology  Beijing China"},{"name":"Key laboratory of Renal Disease Ministry of Health of China  Beijing China"},{"name":"Key Laboratory of Chronic Kidney Disease Prevention and Treatment Ministry of Education of China  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Yu","sequence":"additional","affiliation":[{"name":"Renal Division Department of Medicine Peking University First Hospital Peking University Institute of Nephrology  Beijing China"},{"name":"Key laboratory of Renal Disease Ministry of Health of China  Beijing China"},{"name":"Key Laboratory of Chronic Kidney Disease Prevention and Treatment Ministry of Education of China  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Renal Division Department of Medicine Peking University First Hospital Peking University Institute of Nephrology  Beijing China"},{"name":"Key laboratory of Renal Disease Ministry of Health of China  Beijing China"},{"name":"Key Laboratory of Chronic Kidney Disease Prevention and Treatment Ministry of Education of China  Beijing China"},{"name":"Peking\u2010Tsinghua Center for Life Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60279-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.01.021"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00312"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.191817"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181fc3afa"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2012.11.006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12162"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2014.12.002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(96)02500-X"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2010.07.004"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.09.010"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0b013e3182331028"},{"key":"e_1_2_8_14_1","first-page":"1122","article-title":"Hypertension in pregnancy. 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