{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:05:59Z","timestamp":1757703959962},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T00:00:00Z","timestamp":1471996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>The chronic placental insufficiency is the most common cause of intrauterine hypoxia, retardation of fetal growth, and other threatening conditions. Immune disturbances may occur in the system \u201cmother\u2013placenta\u2013fetus.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Biochemical blood indicators were studied on an automated biochemical analyzer. Pattern of lymphocyte subpopulations was detected by direct membrane immunofluorescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Study revealed imbalance of immune parameters, caused by placental insufficiency (increase natural killers (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>16<jats:sup>+<\/jats:sup>, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>56<jats:sup>+<\/jats:sup>), B lymphocytes (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>19<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3<jats:sup>\u2212<\/jats:sup>), T and B lymphocytes with <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content><jats:sup>+<\/jats:sup> antigen, and early activation of immune cells (by <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25<jats:sup>+<\/jats:sup>), as well as disorders in apoptotic mechanisms (by <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>95<jats:sup>+<\/jats:sup>)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Placental insufficiency leads to abnormalities of the immune system in pregnant, parturient women and maternity patients which were evaluated by localization of activation markers <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>95<jats:sup>+<\/jats:sup> on the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3<jats:sup>+<\/jats:sup>, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup>, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup>, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>16<jats:sup>+<\/jats:sup>, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>56<jats:sup>+<\/jats:sup> lymphocytes. This is reflected in the change of lymphocyte functions in newborns.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12544","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T06:52:50Z","timestamp":1472021570000},"page":"299-306","source":"Crossref","is-referenced-by-count":11,"title":["Metabolic and immunologic aspects of fetoplacental insufficiency"],"prefix":"10.1111","volume":"76","author":[{"given":"Yerbol","family":"Bekmukhambetov","sequence":"first","affiliation":[{"name":"Marat Ospanov West\u2010Kazakhstan State Medical University Aktobe Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arstan","family":"Mamyrbayev","sequence":"additional","affiliation":[{"name":"Marat Ospanov West\u2010Kazakhstan State Medical University Aktobe Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timur","family":"Dzharkenov","sequence":"additional","affiliation":[{"name":"Marat Ospanov West\u2010Kazakhstan State Medical University Aktobe Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Kravtsova","sequence":"additional","affiliation":[{"name":"Scientific Center of Obstetrics Gynecology and Perinatology Ministry of Health of the Republic of Kazakhstan Almaty Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanar","family":"Utesheva","sequence":"additional","affiliation":[{"name":"Scientific Center of Obstetrics Gynecology and Perinatology Ministry of Health of the Republic of Kazakhstan Almaty Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akylbek","family":"Tusupkaliev","sequence":"additional","affiliation":[{"name":"Marat Ospanov West\u2010Kazakhstan State Medical University Aktobe Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Ryzhkova","sequence":"additional","affiliation":[{"name":"Marat Ospanov West\u2010Kazakhstan State Medical University Aktobe Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klara","family":"Darzhanova","sequence":"additional","affiliation":[{"name":"Marat Ospanov West\u2010Kazakhstan State Medical University Aktobe Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maral","family":"Bekzhanova","sequence":"additional","affiliation":[{"name":"Marat Ospanov West\u2010Kazakhstan State Medical University Aktobe Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,24]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1","article-title":"Lactoferrin and its biological functions","volume":"66","author":"Kanyshkova TG","year":"2001","journal-title":"Biochemistry"},{"key":"e_1_2_8_3_1","volume-title":"Basics of perinatal biochemistry","author":"Kayupova NA","year":"1998"},{"key":"e_1_2_8_4_1","first-page":"3","article-title":"The non\u2010developing pregnancy: Etiology, pathogenesis, clinical picture, diagnosis","volume":"2","author":"Nesyaeva EV","year":"2005","journal-title":"Obstet Gynecol"},{"key":"e_1_2_8_5_1","volume-title":"Premature delivery: Endocrine genesis","author":"Raisova AT","year":"2004"},{"key":"e_1_2_8_6_1","first-page":"62","article-title":"Miscarriage \u2013 a modern approach to the problem","volume":"2","author":"Sidelnikova VM","year":"2007","journal-title":"Russ Bull Obstet Gynecol"},{"key":"e_1_2_8_7_1","first-page":"33","article-title":"Prevention of pregnancy complications in women with recurrent premature delivery","volume":"5","author":"Strizhakov AN","year":"2006","journal-title":"Quest Obstet Gynaecol Perinatol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.14341\/probl11837","article-title":"New systems of signals in the hormonal regulation mechanisms","volume":"46","author":"Pankov YA","year":"2000","journal-title":"Problems of Endocrinology"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1510185"},{"key":"e_1_2_8_10_1","volume-title":"Endocrinology of pregnancy. 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