{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:13:56Z","timestamp":1773015236539,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T00:00:00Z","timestamp":1469577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26462489"],"award-info":[{"award-number":["26462489"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25462593"],"award-info":[{"award-number":["25462593"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>The aim of this prospective study was to evaluate phenotypic differences of helper T (Th), cytotoxic T (Tc), and regulatory T (Treg) cells in the deciduae of missed miscarriage with a normal chromosome karyotype of a fetus (<jats:styled-content style=\"fixed-case\">MN<\/jats:styled-content>) and missed miscarriage with an abnormal chromosome karyotype of a fetus (<jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods of study<\/jats:title><jats:p>The decidua of 19 <jats:styled-content style=\"fixed-case\">MN<\/jats:styled-content> and 28 <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content> was obtained. Additionally, the decidua of 15 induced abortion (<jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>) and the endometrium of 19 non\u2010pregnant women (<jats:styled-content style=\"fixed-case\">EM<\/jats:styled-content>) were obtained. <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3<jats:sup>+<\/jats:sup>, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017<jats:sup>+<\/jats:sup>, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25<jats:sup>high<\/jats:sup>Foxp3<jats:sup>+<\/jats:sup> cells in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> (Th) cells, and <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3<jats:sup>+<\/jats:sup> cells in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> (Tc) cells were evaluated by flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The percentages of <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3<jats:sup>+<\/jats:sup> Tc and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25<jats:sup>high<\/jats:sup>Foxp3<jats:sup>+<\/jats:sup> (Treg) cells in <jats:styled-content style=\"fixed-case\">MN<\/jats:styled-content> were significantly increased as compared with <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>. The percentage of <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3<jats:sup>+<\/jats:sup> Th in <jats:styled-content style=\"fixed-case\">MN<\/jats:styled-content> was increased as compared with <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Activation of <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3<jats:sup>+<\/jats:sup> Tc and Treg cells in the decidua might be associated with the pathophysiology underlying <jats:styled-content style=\"fixed-case\">MN<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12546","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T12:02:46Z","timestamp":1469620966000},"page":"199-204","source":"Crossref","is-referenced-by-count":21,"title":["Divergence of helper, cytotoxic, and regulatory T cells in the decidua from miscarriage"],"prefix":"10.1111","volume":"76","author":[{"given":"Yasuhiko","family":"Ebina","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Shimada","sequence":"additional","affiliation":[{"name":"Mommy's Clinic Chitose  Chitose Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Deguchi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Maesawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norifumi","family":"Iijima","sequence":"additional","affiliation":[{"name":"Department of Immunobiology Yale University School of Medicine  New Haven USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideto","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,27]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"Spontaneous Abortion Risks in Man: Data from Reproductive Histories Collected in a Medical Genetics Unit","volume":"16","author":"Warburton D","year":"1964","journal-title":"Am J Hum Genet"},{"key":"e_1_2_7_3_1","first-page":"656","article-title":"Cytogenetic analysis of 750 spontaneous abortions with the direct\u2010preparation method of chorionic 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