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On<jats:styled-content style=\"fixed-case\">GD<\/jats:styled-content>19, blood\u2013brain barrier (<jats:styled-content style=\"fixed-case\">BBB<\/jats:styled-content>) permeability was evaluated via Evan's Blue infusion, blood was collected for T\u2010cell measurements, inflammatory cytokine secretion. Brain tissues were also collected to examine inflammatory cytokine infiltration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>T\u2010cell attenuation with Orencia decreased circulating<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup>and<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup>T cells, circulating tumor necrosis factor alpha (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u03b1) and<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017,<jats:styled-content style=\"fixed-case\">BBB<\/jats:styled-content>permeability and significantly decreased biochemical evidence of<jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content>compared to untreated<jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content>rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data support the hypothesis that T cells have a critical role in contributing to the pathophysiology that is seen in angiogenic imbalance during pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12547","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T16:04:14Z","timestamp":1470153854000},"page":"272-279","source":"Crossref","is-referenced-by-count":23,"title":["Inhibition of T\u2010cell activation attenuates hypertension,<scp>TNF<\/scp>\u03b1,<scp>IL<\/scp>\u201017, and blood\u2013brain barrier permeability in pregnant rats with angiogenic imbalance"],"prefix":"10.1111","volume":"76","author":[{"given":"Cynthia","family":"Bean","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of Mississippi Medical Center Jackson MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shauna\u2010Kay","family":"Spencer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology 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