{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:04:21Z","timestamp":1792008261283,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T00:00:00Z","timestamp":1471478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009602","name":"Howard and Georgeanna Jones Foundation for Reproductive Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Autoimmunity is thought to be an important cause of premature ovarian senescence, characterized by abnormal ovarian reserve markers. Anti\u2010Mullerian hormone (<jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>) has emerged as the most reliable marker for ovarian reserve. We here investigated whether non\u2010specific immune markers are associated with a low age\u2010specific <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>To test the hypothesis that autoimmunity may predispose to low <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>, we investigated in 351 female infertile patients whether panels positive for non\u2010specific immune tests (antinuclear antibody, antiphospholipid antibodies [<jats:styled-content style=\"fixed-case\">APA<\/jats:styled-content>s], lupus anticoagulant, antithyroid antibodies, and total immunoglobulin levels) are associated with low <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> levels. Analysis of covariance was performed to determine statistical significance of associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Age of infertile women was 38.6\u00a0\u00b1\u00a05.3\u00a0years. A total of 50 women (14.2%) had abnormally elevated levels of one or more <jats:styled-content style=\"fixed-case\">APA<\/jats:styled-content>. Even after age adjustments, the presence of at least one <jats:styled-content style=\"fixed-case\">APA<\/jats:styled-content> was significantly associated with a low <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> (<jats:italic>P<\/jats:italic>&lt;.0066). No one specific <jats:styled-content style=\"fixed-case\">APA<\/jats:styled-content> or other immune marker demonstrated an association with <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">APA<\/jats:styled-content>s but no other immune markers appear associated with decreased levels of <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>, supporting the hypothesis that non\u2010specific autoimmunity may adversely affect ovarian reserve.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12551","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T04:42:56Z","timestamp":1471581776000},"page":"333-337","source":"Crossref","is-referenced-by-count":29,"title":["Anti\u2010mullerian hormone levels decline with the presence of antiphospholipid antibodies"],"prefix":"10.1111","volume":"76","author":[{"given":"Mario","family":"Vega","sequence":"first","affiliation":[{"name":"The Center for Human Reproduction  New York NY USA"},{"name":"Department of Obstetrics and Gynecology Albert Einstein College of Medicine  Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Barad","sequence":"additional","affiliation":[{"name":"The Center for Human Reproduction  New York NY USA"},{"name":"Department of Obstetrics and Gynecology Albert Einstein College of Medicine  Bronx NY USA"},{"name":"Foundation for Reproductive Medicine  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yu","sequence":"additional","affiliation":[{"name":"The Center for Human Reproduction  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Darmon","sequence":"additional","affiliation":[{"name":"The Center for Human Reproduction  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