{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T21:57:42Z","timestamp":1778018262332,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T00:00:00Z","timestamp":1473811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006710","name":"Wayne State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Preterm neonates are highly susceptible to infection. Neonatal host defense against infection seems to be maintained by the temporal presence of immunosuppressive <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>71+ erythroid cells. The aim of this study was to investigate whether umbilical cord <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>71+ erythroid cells are reduced in neonates born to women who undergo spontaneous preterm labor\/birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Umbilical cord blood samples (n=155) were collected from neonates born to women who delivered preterm with (n=39) and without (n=12) spontaneous labor or at term with (n=82) and without (n=22) spontaneous labor. Time\u2010matched maternal peripheral blood samples were also included (n=111). Mononuclear cells were isolated from these samples, and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>71+ erythroid cells were identified and quantified as <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>235a+<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>71+ cells by flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>(i) The proportion of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>71+ erythroid cells was 50\u2010fold higher in cord blood than in maternal blood; (ii) a reduced number and frequency of umbilical cord <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>71+ erythroid cells were found in neonates born to women who underwent spontaneous preterm labor compared to those born to women who delivered preterm without labor; (iii) umbilical cord <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>71+ erythroid cells were fewer in neonates born to term pregnancies, regardless of the process of labor, than in those born to women who delivered preterm without labor; and (iv) no differences were seen in umbilical cord <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>71+ erythroid cells between neonates born to women who underwent spontaneous preterm labor and those born to women who delivered at term with labor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Umbilical cord <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>71+ erythroid cells are reduced in neonates born to women who had undergone spontaneous preterm labor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12556","type":"journal-article","created":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T10:32:45Z","timestamp":1473849165000},"page":"280-284","source":"Crossref","is-referenced-by-count":24,"title":["Umbilical cord <scp>CD<\/scp>71+ erythroid cells are reduced in neonates born to women in spontaneous preterm labor"],"prefix":"10.1111","volume":"76","author":[{"given":"Nardhy","family":"Gomez\u2010Lopez","sequence":"first","affiliation":[{"name":"Perinatology Research Branch, Program for Perinatal Research and Obstetrics Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development, NICHD\/NIH\/DHHS  Bethesda MD and Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology Wayne State University School of Medicine  Detroit MI USA"},{"name":"Department of Immunology and Microbiology Wayne State University School of Medicine  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Romero","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Program for Perinatal Research and Obstetrics Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development, NICHD\/NIH\/DHHS  Bethesda MD and Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology University of Michigan  Ann Arbor MI USA"},{"name":"Department of Epidemiology and Biostatistics Michigan State University  East Lansing MI USA"},{"name":"Center for Molecular Medicine and Genetics Wayne State University  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Xu","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Program for Perinatal Research and Obstetrics Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development, NICHD\/NIH\/DHHS  Bethesda MD and Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology Wayne State University School of Medicine  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek","family":"Miller","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Program for Perinatal Research and Obstetrics Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development, NICHD\/NIH\/DHHS  Bethesda MD and Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology Wayne State University School of Medicine  Detroit MI USA"},{"name":"Department of Immunology and Microbiology Wayne State University School of Medicine  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Unkel","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Program for Perinatal Research and Obstetrics Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development, NICHD\/NIH\/DHHS  Bethesda MD and Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology Wayne State University School of Medicine  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tippi","family":"C. MacKenzie","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center of Regeneration Medicine and the Department of Surgery University of California  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Frascoli","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center of Regeneration Medicine and the Department of Surgery University of California  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia S.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Program for Perinatal Research and Obstetrics Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development, NICHD\/NIH\/DHHS  Bethesda MD and Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology Wayne State University School of Medicine  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61698-6"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Births: final data for 2013","volume":"64","author":"Martin JA","year":"2015","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251816"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61577-8"},{"issue":"426","key":"e_1_2_7_7_1","first-page":"e421","article-title":"Correlation between initial neonatal and early childhood outcomes following preterm birth","volume":"210","author":"Manuck TA","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71048-5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61712-8"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.10.014"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.3764"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12675"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500771"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071204"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.obstetgynecol.2003.10.011"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2007.09.003"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.73"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0320(19970101)27:1<71::AID-CYTO9>3.0.CO;2-O"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2014.177"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00376"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faji.12556","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faji.12556","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.12556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T22:08:15Z","timestamp":1696370895000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.12556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,14]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/aji.12556"],"URL":"https:\/\/doi.org\/10.1111\/aji.12556","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,14]]}}}