{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:15:57Z","timestamp":1791764157443,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Science and Technology Project of Health"},{"name":"Family Planning Commission of Shenzhen Municipality","award":["201506096"],"award-info":[{"award-number":["201506096"]}]},{"name":"Basic Research Programs of Shenzhen","award":["JCYJ20160427113303899"],"award-info":[{"award-number":["JCYJ20160427113303899"]}]},{"name":"Basic Research Programs of Shenzhen","award":["JCYJ20160427113153295"],"award-info":[{"award-number":["JCYJ20160427113153295"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>We aimed to investigate the modulatory effects of vitamin D on peripheral blood cellular immune response in patients with recurrent miscarriage (<jats:styled-content style=\"fixed-case\">RM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>The effect of vitamin D on the number of peripheral blood cells, T helper 1 (Th1) cytokines, and <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cytotoxicity was measured in 99 women with <jats:styled-content style=\"fixed-case\">RM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The percentage of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>19<jats:sup>+<\/jats:sup> B cells and <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cytotoxicity at an effector\u2010to\u2010target cell (E:T) ratio of 50:1, 25:1, and 12.5:1 were significantly higher in the vitamin D insufficiency group (<jats:styled-content style=\"fixed-case\">VDI<\/jats:styled-content>) than in the vitamin D normal group (<jats:styled-content style=\"fixed-case\">VDN<\/jats:styled-content>) (<jats:italic>P<\/jats:italic>&lt;.05 each). The proportion of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1\u2010expressing Th cells was significantly higher in the vitamin D deficiency group (<jats:styled-content style=\"fixed-case\">VDD<\/jats:styled-content>) than in <jats:styled-content style=\"fixed-case\">VDN<\/jats:styled-content> (<jats:italic>P<\/jats:italic>&lt;.05). However, there were no significant differences between <jats:styled-content style=\"fixed-case\">VDI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">VDD<\/jats:styled-content>. This dysregulation was significantly reduced with 1,25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)<jats:sub>2<\/jats:sub>D supplementation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The data suggest that the abnormalities of cellular immune response were observed in <jats:styled-content style=\"fixed-case\">RM<\/jats:styled-content> patients with a low vitamin D level, which could be regulated to some extent with 1,25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)<jats:sub>2<\/jats:sub>D supplementation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12585","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T11:46:32Z","timestamp":1475840792000},"page":"432-438","source":"Crossref","is-referenced-by-count":35,"title":["Modulatory effects of vitamin D on peripheral cellular immunity in patients with recurrent 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