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We concluded that a period of remission with minimal or no therapy before conception could significantly reduce the risk of the disease flaring up, at least in the first trimester. The period of remission causes a delay in the flare\u2010up of the disease, which means lower cumulative doses and the prevention of possible congenital abnormalities caused by corticosteroid or immunosuppressant treatments. All common treatments of pemphigus\u2014azathioprine, mycophenolate mofetil, and methotrexate\u2014should be avoided during pregnancy. However, it appears that systemic corticosteroids in a safe dose with a topical form of corticosteroids may be used without serious risk. Due to the lack of data associated with rituximab therapy, it is recommended that this drug be avoided 12\u00a0months before conception. It appears that the safest treatment of pemphigus is intravenous immunoglobulin (<jats:styled-content style=\"fixed-case\">IVI<\/jats:styled-content>g), which may be more effective when used with topical corticosteroids. 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