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Little is known about pathophysiology of <jats:styled-content style=\"fixed-case\">ZVI<\/jats:styled-content> because it has been regarded as a mild, no life\u2010threatening infection. However, the latest endemic in South and Central America took attention of perinatologists, microbiologists, and pathologists. Both in vivo and in vitro studies suggest neurotropic nature of Zika virus but do not clarify viral kinetics during vertical transmissions. In this review, we focus on the clinical and microbiological natures <jats:styled-content style=\"fixed-case\">ZVI<\/jats:styled-content> for pregnant women especially how placental barriers are broken down.<\/jats:p>","DOI":"10.1111\/aji.12605","type":"journal-article","created":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T05:12:49Z","timestamp":1481692369000},"source":"Crossref","is-referenced-by-count":4,"title":["Mechanisms and possible controls of the in utero Zika virus infection: Where is the Holy Grail?"],"prefix":"10.1111","volume":"77","author":[{"given":"Kazumasa","family":"Fuwa","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Child Health Nihon University School of Medicine Itabashi\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Division of Microbiology Department of Pathology and Microbiology Nihon University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(52)90042-4"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(54)90006-1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805715"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES2014.19.13.20751"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf8160"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2207.160375"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602412"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004636"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30006-8"},{"key":"e_1_2_11_11_1","unstructured":"WHO.Zika virus Microcephaly and Guillain\u2010Barr\u00e9 syndrome. 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