{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:16:56Z","timestamp":1789993016544,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T00:00:00Z","timestamp":1479686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001793","name":"Queensland University of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">pIgR<\/jats:styled-content> mediates transport of IgA into the lumen of mucosal tissues preventing pathogenic infection. Despite this, the expression of <jats:styled-content style=\"fixed-case\">pIgR<\/jats:styled-content> during chlamydial infections of the male and female reproductive tracts remains poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>The expression of <jats:styled-content style=\"fixed-case\">pIgR<\/jats:styled-content> in response to hormone cycling or over the course of chlamydial infection was determined in vitro and in vivo by Western blot or immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>gR was upregulated in response to <jats:italic>Chlamydia<\/jats:italic> spp. infection of human epithelia, in both male and female mouse reproductive tracts. <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>gR expression was found to be highest during estrus in the cervicovaginal and uterine epithelia and lowest during diestrus or following hormonal synchronization with Depo\u2010Provera. Chlamydial infection of mice mediates upregulation of <jats:styled-content style=\"fixed-case\">pIgR<\/jats:styled-content> and transcytosis of IgA into the lumen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that chlamydial infection enhances IgA secretion and <jats:styled-content style=\"fixed-case\">pIgR<\/jats:styled-content> expression by epithelia in the lower reproductive tracts of females and males, and hormone synchronization downregulates <jats:styled-content style=\"fixed-case\">pIgR<\/jats:styled-content> expression and transcytosis of IgA prior to challenge.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12611","type":"journal-article","created":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T07:47:04Z","timestamp":1479714424000},"source":"Crossref","is-referenced-by-count":16,"title":["Chlamydial infection enhances expression of the polymeric immunoglobulin receptor (<scp>pIgR<\/scp>) and transcytosis of 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