{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:32:32Z","timestamp":1791415952805,"version":"4.3.3"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T00:00:00Z","timestamp":1481673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01A1AI121183"],"award-info":[{"award-number":["R01A1AI121183"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["5T32 AI007019\u201040"],"award-info":[{"award-number":["5T32 AI007019\u201040"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI121183"],"award-info":[{"award-number":["R01AI121183"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32 AI007019\u201040"],"award-info":[{"award-number":["5T32 AI007019\u201040"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>Recent studies have linked antenatal infection with Zika virus (<jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content>) with major adverse fetal and neonatal outcomes, including microcephaly. There is a growing consensus for the existence of a congenital Zika syndrome (<jats:styled-content style=\"fixed-case\">CZS<\/jats:styled-content>). Previous studies have indicated that non\u2010placental macrophages play a key role in the replication of dengue virus (<jats:styled-content style=\"fixed-case\">DENV<\/jats:styled-content>), a closely related flavivirus. As the placenta provides the conduit for vertical transmission of certain viruses, and placental Hofbauer cells (<jats:styled-content style=\"fixed-case\">HBC<\/jats:styled-content>s) are fetal\u2014placental macrophages located adjacent to fetal capillaries, it is not surprising that several recent studies have examined infection of <jats:styled-content style=\"fixed-case\">HBC<\/jats:styled-content>s by <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content>. In this review, we describe congenital abnormalities associated with <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infection, the role of <jats:styled-content style=\"fixed-case\">HBC<\/jats:styled-content>s in the placental response to infection, and evidence for the susceptibility of <jats:styled-content style=\"fixed-case\">HBC<\/jats:styled-content>s to <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infection. We conclude that <jats:styled-content style=\"fixed-case\">HBC<\/jats:styled-content>s may contribute to the spread of <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> in placenta and promote vertical transmission of <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content>, ultimately compromising fetal and neonatal development and function. Current evidence strongly suggests that further studies are warranted to dissect the specific molecular mechanism through which <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infects <jats:styled-content style=\"fixed-case\">HBC<\/jats:styled-content>s and its potential impact on the development of <jats:styled-content style=\"fixed-case\">CZS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/aji.12613","type":"journal-article","created":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T13:29:59Z","timestamp":1481808599000},"source":"Crossref","is-referenced-by-count":102,"title":["Zika virus infection of Hofbauer cells"],"prefix":"10.1111","volume":"77","author":[{"given":"Michael K.","family":"Simoni","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences Yale School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellie Ann","family":"Jurado","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases Department of Internal Medicine Yale School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikki M.","family":"Abrahams","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences Yale School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"Fikrig","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases Department of Internal Medicine Yale School of Medicine New Haven CT USA"},{"name":"Howard Hughes Medical Institute Chevy Chase MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth","family":"Guller","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences Yale School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1604338"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)00095-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602412"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600651"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30776-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i1901"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1604037"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.3720"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12289"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12355"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2016\u20100401\u2010OA"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2012.02.004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7733"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004517"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1605898"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237612"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-4199-5_6"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2008.02964.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803834"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2011.01006.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.02.003"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2010.03.003"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2004.08.008"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod62.4.1075"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2007.01.010"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4133"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59643"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12336"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2010.00927.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12112"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2003.09.005"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2005.02.009"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.5.1668S"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2004.01.015"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2003.12.015"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040706"},{"key":"e_1_2_6_38_1","first-page":"10","article-title":"The role of co\u2010infections in mother\u2010to\u2010child transmission of HIV","volume":"11","author":"King CC","year":"2013","journal-title":"Curr HIV Res"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.278.3.R677"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(96)90019-3"},{"key":"e_1_2_6_41_1","first-page":"855","article-title":"Trophoblast interaction with fibrin matrix. Epithelialization of perivillous fibrin deposits as a mechanism for villous repair in the human placenta","volume":"136","author":"Nelson DM","year":"1990","journal-title":"Am J Pathol"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1086\/518007"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2009.80.416"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/77553"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.05.015"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.88461"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760160085"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.07.002"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.008"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faji.12613","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.12613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:24:15Z","timestamp":1695540255000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.12613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,14]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/aji.12613"],"URL":"https:\/\/doi.org\/10.1111\/aji.12613","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,14]]},"article-number":"e12613"}}