{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:27:28Z","timestamp":1753878448445,"version":"3.41.2"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T00:00:00Z","timestamp":1481760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>The pandemic spread of Zika virus (<jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content>), a member of the <jats:italic>flavivirus<\/jats:italic> genus of the <jats:italic>Flaviviridae<\/jats:italic> family, has become a major public health concern. Reproductive specialists are particularly concerned over the spread of <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> as it is now known to have both sexual and transplacental routes of transmission resulting in fetal congenital abnormalities. Other members of the <jats:italic>Flaviviridae<\/jats:italic> family, hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) and bovine viral diarrhea virus (<jats:styled-content style=\"fixed-case\">BVDV<\/jats:styled-content>) (which primarily affects cattle), are well known to reproductive specialists as both sexually transmitted illnesses that are capable of vertical transmission. Congenital infection with <jats:styled-content style=\"fixed-case\">BVDV<\/jats:styled-content> also has a predilection for neuro\u2010teratogenicity as has been seen with <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BVDV<\/jats:styled-content> are also known to be capable of persistent infection in offspring. Could this be the case with <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content>? Examining what we know about <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BVDV<\/jats:styled-content>, in addition to what we have already learned about <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content>, may answer some of the questions that remain about <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content>. Herein, we review the current literature as it pertains to <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> vertical transmission and neuro\u2010teratogenicity and compare it to what is known about <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BVDV<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/aji.12615","type":"journal-article","created":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T16:58:49Z","timestamp":1481821129000},"source":"Crossref","is-referenced-by-count":4,"title":["Zika virus: Future reproductive concerns"],"prefix":"10.1111","volume":"77","author":[{"given":"Christopher M.","family":"Novak","sequence":"first","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine Department of Gynecology and Obstetrics Integrated Research Center for Fetal Medicine Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne S.","family":"Sheffield","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine Department of Gynecology and Obstetrics Integrated Research Center for Fetal Medicine Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Burd","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine Department of Gynecology and Obstetrics Integrated Research Center for Fetal Medicine Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1602113"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.06.040"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2024"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1709.110242"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600651"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.16.176990"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805715"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00651-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0150-2016"},{"key":"e_1_2_6_11_1","unstructured":"Centers for Disease Control and Prevention.Zika Virus: Case Counts in the US.https:\/\/www.cdc.gov\/zika\/geo\/united-states.html. 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