{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:31Z","timestamp":1787013811889,"version":"build-2736575974"},"reference-count":78,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,3]],"date-time":"2017-01-03T00:00:00Z","timestamp":1483401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>\n                    In May 2015, the first episodes of Zika virus infection of the Latin America were confirmed in Brazil, where currently 196\u00a0976 cases were reported. The main route of transmission occurs by Aedes mosquitoes, and the most common symptoms are maculopapular rash, fever, conjunctivitis, polyarthralgia, and periarticular edema. However, the infection is asymptomatic in 80% of the cases. The congenital infection is characterized when the transmission to the fetus occurs during pregnancy, but the mechanisms of how the virus infects the placenta remain unclear. Anatomopathological findings were described in first\u2010 and third\u2010trimester human placentas; however, the major affected tissue of the baby is the neural. Several clinical situations were listed in these fetuses, such as neurological, ophthalmological, auditory, and articular alterations. The World Health Organization proposed a new congenital syndrome caused by Zika virus. The virus has an important neurotropism and the main manifestation observed in the syndrome is microcephaly, which is usually severe and associated with other neurological injuries. The appearance of sudden rash in pregnant women determines immediate investigation through\n                    <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\n                    and serological analysis. Moreover, the prevention consists in using repellents and avoiding endemic areas, considering that the vaccine is still under development.\n                  <\/jats:p>","DOI":"10.1111\/aji.12616","type":"journal-article","created":{"date-parts":[[2017,1,3]],"date-time":"2017-01-03T07:56:59Z","timestamp":1483430219000},"source":"Crossref","is-referenced-by-count":24,"title":["Zika virus and pregnancy: An overview"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7561-4566","authenticated-orcid":false,"given":"Newton S\u00e9rgio","family":"de Carvalho","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Infectious Diseases in Gynecology and Obstetrics Sector Clinics Hospital Federal University of Parana  Curitiba PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Freitas","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Pontifical Catholic University of Parana  Curitiba PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"D\u00f3ris","sequence":"additional","affiliation":[{"name":"Pontifical Catholic University of Parana  Curitiba PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evellyn","family":"Silverio Biscaia","sequence":"additional","affiliation":[{"name":"Pontifical Catholic University of Parana  Curitiba PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyllian","family":"Arias Fuga\u00e7a","sequence":"additional","affiliation":[{"name":"Pontifical Catholic University of Parana  Curitiba PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00facia","family":"de Noronha","sequence":"additional","affiliation":[{"name":"Pontifical Catholic University of Parana  Curitiba PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2207.151990"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtm.2016.05.020"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2016.02.006"},{"key":"e_1_2_11_5_1","unstructured":"Zika situation report \u2013 emergencies. 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