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The important factors involved in inflammation associated with endometriosis are chemokines, especially interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20108. For this reason, the current study briefly reviews the role of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 in the pathogenesis of endometriosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>A systematic review was done on all published studies that compared IL\u20108 expression and concentration in patients with and without endometriosis to evaluate their potential as biomarkers for the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 induces chemotaxis of neutrophils and other immune cells; also, it is a potent angiogenic agent. Most researchers pointed to the increased peritoneal and serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 levels and showed correlation with the severity of the disease, size and number of the active lesions. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 takes part in all processes during the development of the disease: adhesion, invasion, and implantation of ectopic tissue. Additionally, the chemokine plays a role in growth and maintenance of ectopic endometrial tissue directly affecting endometrial cell proliferation. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 might also protect ectopic cells against death by apoptosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It may act as an autocrine growth factor in the endometrium and promotes the vicious circle of endometrial cell attachment and, in consequence, may lead to a transformation from acute to chronic inflammation stage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12622","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T05:42:59Z","timestamp":1485322979000},"source":"Crossref","is-referenced-by-count":111,"title":["Abnormal peritoneal regulation of chemokine activation\u2014The role of <scp>IL<\/scp>\u20108 in pathogenesis of 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