{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:41:50Z","timestamp":1780983710898,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI","award":["26462490"],"award-info":[{"award-number":["26462490"]}]},{"name":"JSPS KAKENHI","award":["15K10671"],"award-info":[{"award-number":["15K10671"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2017,4]]},"abstract":"Problem<\/jats:title>Is lipopolysaccharide (LPS<\/jats:styled-content>) involved in the development of endometriosis?<\/jats:p><\/jats:sec>Method of Study<\/jats:title>BALB<\/jats:styled-content>\/c mice (n=69) were used for the murine endometriosis model. Mice with surgically induced endometriosis were injected with LPS<\/jats:styled-content> intraperitoneally. After 4 weeks of LPS<\/jats:styled-content> injections with or without the nuclear factor\u2010kappa B (NF<\/jats:styled-content>\u2010\u03baB) inhibitor, the extent of endometriosis\u2010like lesions was evaluated. Expression of inflammatory factors in the implants was evaluated using real\u2010time RT<\/jats:styled-content>\u2010PCR<\/jats:styled-content>. Cell proliferation, angiogenic activity, inflammation, and NF<\/jats:styled-content>\u2010\u03baB phosphorylation were assessed by immunohistochemical staining.<\/jats:p><\/jats:sec>Results<\/jats:title>Lipopolysaccharide increased total number, size, and mRNA<\/jats:styled-content> expression of Ptgs\u20102, Vegf<\/jats:italic>, Ccl\u20102,<\/jats:italic> and Il\u20106<\/jats:italic> in endometriosis\u2010like lesions. LPS<\/jats:styled-content> also increased the percentage of Ki67\u2010positive cells and enhanced the intensity and rate of positive cells of CD<\/jats:styled-content>3, F4\/80, and PECAM<\/jats:styled-content>. Intense expression of phospho\u2010NF<\/jats:styled-content>\u2010\u03baB p65 after LPS<\/jats:styled-content> administration was observed. Treatment with the NF<\/jats:styled-content>\u2010kB<\/jats:styled-content> inhibitor negated these LPS<\/jats:styled-content>\u2010induced effects.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>LPS<\/jats:styled-content>\u2010induced pelvic inflammation status enhanced the development of murine endometriosis\u2010like lesions via <\/jats:italic>NF<\/jats:styled-content>\u2010\u03baB pathway.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12631","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T07:23:47Z","timestamp":1485847427000},"source":"Crossref","is-referenced-by-count":48,"title":["Lipopolysaccharide promotes the development of murine endometriosis\u2010like lesions via the nuclear factor\u2010kappa B pathway"],"prefix":"10.1111","volume":"77","author":[{"given":"Yukihiro","family":"Azuma","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Tottori University Faculty of Medicine Yonago 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