{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:54:16Z","timestamp":1774583656780,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T00:00:00Z","timestamp":1490140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Juravinski Cancer Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Expression of<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>200 at the feto\u2010maternal interface is associated with successful murine and human pregnancy.<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>200 binding to<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>200 receptors on lymphomyeloid cells suppresses inflammation and induces Tregs.<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>200 receptors are also expressed on mouse and human placental trophoblast cells. What is the expression of<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>200 and<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>200R in human missed abortions which have preserved Treg levels and in chronic histiocytic intervillositis (<jats:styled-content style=\"fixed-case\">CHI<\/jats:styled-content>) where maternal inflammatory cells cause<jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>?<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Immunohistiochemistry for<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>200,<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>200R, and Ki67 using human placental sections from missed abortions, term placenta, and<jats:styled-content style=\"fixed-case\">CHI<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>testing was done for trisomy in missed abortion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>200 and<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>200R were expressed by human villus trophoblasts from 2\u00a0weeks post\u2010implantation to term. Cytotrophoblast proliferation (Ki\u201067<jats:sup>+<\/jats:sup>count) decreased at term. In first trimester missed abortion cases,<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>200&gt;<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>200R villus trophoblasts accompanied missed abortion of non\u2010trisomic male fetuses.<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>200 and Ki67<jats:sup>+<\/jats:sup>trophoblast proliferation was preserved in<jats:styled-content style=\"fixed-case\">CHI<\/jats:styled-content>with maternal inflammatory cell infiltration but<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>200R was greatly decreased.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Residual<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>200 activity may prevent completion of abortions via induction of Treg cells. In<jats:styled-content style=\"fixed-case\">CHI<\/jats:styled-content>, infiltrating maternal effector T cells may block Treg induction. An autocrine role for<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>200\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>200R interaction versus inhibition of soluble<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>200 by soluble<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>200R is discussed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12665","type":"journal-article","created":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T05:22:15Z","timestamp":1490246535000},"source":"Crossref","is-referenced-by-count":18,"title":["Changes in expression of the<scp>CD<\/scp>200 tolerance\u2010signaling molecule and its receptor (<scp>CD<\/scp>200R) by villus trophoblasts during first trimester missed abortion and in chronic histiocytic intervillositis"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8032-1028","authenticated-orcid":false,"given":"David A.","family":"Clark","sequence":"first","affiliation":[{"name":"Department of Medicine McMaster University Hamilton Ontario Canada"},{"name":"Department of Pathology and Molecular Medicine McMaster University Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer M.","family":"Dmetrichuk","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine McMaster University Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"McCready","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine McMaster University Hamilton Ontario Canada"},{"name":"Genetics Services Hamilton Regional Laboratory Medicine Program Hamilton Health Sciences Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukhbinder","family":"Dhesy\u2010Thind","sequence":"additional","affiliation":[{"name":"Department of Oncology McMaster University Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge L.","family":"Arredondo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine McMaster University Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,22]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"89","article-title":"Mouse is the new woman? 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