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Recombinant <jats:styled-content style=\"fixed-case\">IFNA<\/jats:styled-content>2 imparted chemosensitive choriocarcinoma cells with partial resistance to methotrexate, while chemoresistant choriocarcinoma cells were uniquely sensitive to fludarabine, a <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>1 inhibitor. In pre\u2010treatment patient sera, <jats:styled-content style=\"fixed-case\">IFNA<\/jats:styled-content>2 levels correlated with subsequent resistance to methotrexate chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Methotrexate resistance is influenced by type I interferon signaling with prognostic and therapeutic implications for treating women with <jats:styled-content style=\"fixed-case\">GTN<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12666","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T21:14:06Z","timestamp":1489526046000},"source":"Crossref","is-referenced-by-count":12,"title":["Type I interferons modulate methotrexate resistance in gestational trophoblastic neoplasia"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1502-5553","authenticated-orcid":false,"given":"Kevin M.","family":"Elias","sequence":"first","affiliation":[{"name":"New 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