{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T04:13:41Z","timestamp":1774671221692,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:00:00Z","timestamp":1490313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2012R1A1A4A01003887"],"award-info":[{"award-number":["2012R1A1A4A01003887"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Problem<\/jats:title>In this study, we aim to investigate if the expression of TWIST<\/jats:styled-content> in the first\u2010trimester placenta and decidua has any association with spontaneous abortion (SAB<\/jats:styled-content>) and recurrent pregnancy losses (RPL<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Expression of TWIST<\/jats:styled-content> was measured in the first\u2010trimester trophoblast and decidual tissues using RT<\/jats:styled-content>\u2010PCR<\/jats:styled-content> and immunohistochemistry. Women with a pregnancy loss comprised the study group (AB<\/jats:styled-content> group) including women with two or more recurrent pregnancy loses (RPL<\/jats:styled-content> group), and women with a spontaneous abortion who had no history of previous pregnancy losses (SAB<\/jats:styled-content> group). Controls were women with elective abortion of normal pregnancy (NP<\/jats:styled-content> group).<\/jats:p><\/jats:sec>Results<\/jats:title>In in\u2010vitro culture study of endometrial cells, expression of TWIST<\/jats:styled-content> was detected with the induction of decidualization. In syncytiotrophoblast, expression of TWIST<\/jats:styled-content> in NP<\/jats:styled-content> group was significantly higher than that of AB<\/jats:styled-content> group. RPL<\/jats:styled-content> group had no expression of TWIST<\/jats:styled-content>, both in the nucleus and cytoplasm of syncytiotrophoblast. In decidual tissue, majority of TWIST<\/jats:styled-content> was expressed on the decidual stromal cells. NP<\/jats:styled-content> group showed significantly higher expression of TWIST<\/jats:styled-content> in cytoplasm and nucleus as compared with those of SAB<\/jats:styled-content> group.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This suggests that TWIST<\/jats:styled-content> may have a functional role in decidualization of endometrial cells and syncytialization of cytotrophoblast cells.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12670","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T11:59:01Z","timestamp":1490356741000},"source":"Crossref","is-referenced-by-count":9,"title":["Expression of TWIST<\/scp> in the first\u2010trimester trophoblast and decidual tissue of women with recurrent pregnancy losses"],"prefix":"10.1111","volume":"78","author":[{"given":"Jin Hee","family":"Ahn","sequence":"first","affiliation":[{"name":"Laboratory of Reproductive Medicine Cheil General Hospital & Women's Healthcare Center College of Medicine Dankook 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