{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:25:04Z","timestamp":1780374304765,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T00:00:00Z","timestamp":1490832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>To determine if maternal immune maladaptation associated with pre\u2010eclampsia is reflected in the rubella immunity status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Incidence of pre\u2010eclampsia was compared between rubella non\u2010immune and immune gravidae carrying a singleton pregnancy beyond 24\u00a0weeks, taking into account maternal characteristics and reported risk factors for pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 9870 (10.4%) rubella non\u2010immune gravidae among the 95\u00a0024 in the cohort exhibited no difference in incidence of underlying medical disorders, but they were slightly but significantly older, shorter, heavier, and had more pre\u2010eclampsia (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>1.24, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>1.05\u20101.47) despite having fewer nulliparas. Regression analysis confirmed an overall association between rubella non\u2010immunity with pre\u2010eclampsia (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>1.27, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>1.06\u20101.54), which was related to multiparas (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>1.42, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>1.05\u20101.91) and carrying a male fetus (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>1.37, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>1.06\u20101.78).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The association between rubella non\u2010immunity and pre\u2010eclampsia reflects immune maladaptation in multiparas and toward a male fetus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12677","type":"journal-article","created":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T18:35:34Z","timestamp":1490898934000},"source":"Crossref","is-referenced-by-count":7,"title":["Maternal rubella immunity status and pre\u2010eclampsia"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7315-8747","authenticated-orcid":false,"given":"Terence T.","family":"Lao","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology The Chinese University of Hong Kong and Prince of Wales Hospital Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daljit S.","family":"Sahota","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology The Chinese University of Hong Kong and Prince of Wales Hospital Shatin Hong 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