{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:27:22Z","timestamp":1787610442015,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T00:00:00Z","timestamp":1494547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["PRVOUK P32"],"award-info":[{"award-number":["PRVOUK P32"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["PROGRES Q34"],"award-info":[{"award-number":["PROGRES Q34"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Problem<\/jats:title>Investigating the stress response in the central cotyledon zone of placental tissue in pregnancies with PPROM<\/jats:styled-content>, PTB<\/jats:styled-content>, and at term in labor.<\/jats:p><\/jats:sec>Method of study<\/jats:title>Gene expression of Hsp27, Hsp60, Hsp70, Hsp90, and HspBP<\/jats:styled-content>1 was compared between these particular groups. Correlation between variables including Hsp gene expression in placental tissue and the gestational age at delivery, WBC<\/jats:styled-content> count at admission, and serum levels of CRP<\/jats:styled-content> at admission in patients with PPROM<\/jats:styled-content> and PTB<\/jats:styled-content> was determined.<\/jats:p><\/jats:sec>Results<\/jats:title>Both PPROM<\/jats:styled-content> and PTB<\/jats:styled-content> pregnancies were associated with altered Hsp gene expression profile. While PPROM<\/jats:styled-content> and PTB<\/jats:styled-content> always induced upregulation of Hsp27 and Hsp60, downregulation of Hsp70 and HspBP<\/jats:styled-content>1 was present entirely in patients with PPROM<\/jats:styled-content>. HspBP<\/jats:styled-content>1 expression profile was also able to differentiate between PPROM<\/jats:styled-content> and PTB<\/jats:styled-content> pregnancies. The highest mRNA<\/jats:styled-content> levels of Hsp60 and Hsp70 were detected in PTB<\/jats:styled-content> pregnancies with elevated CRP<\/jats:styled-content> levels at admission. Some of the examined Hsp displayed increased expression with advancing gestational age in both groups (PPROM<\/jats:styled-content>: Hsp27, Hsp70, and Hsp90; and PTB<\/jats:styled-content>: Hsp27).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Upregulation of Hsp27 is a common phenomenon shared between pregnancies affected with PTB<\/jats:styled-content> and PPROM<\/jats:styled-content>. On the other hand, downregulation of Hsp70 and HspBP<\/jats:styled-content>1 represents a unique feature of PPROM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12698","type":"journal-article","created":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T09:33:11Z","timestamp":1494581591000},"source":"Crossref","is-referenced-by-count":12,"title":["Expression profile of heat shock proteins in placental tissues of patients with preterm prelabor rupture of membranes and spontaneous preterm labor with intact membranes"],"prefix":"10.1111","volume":"78","author":[{"given":"Lenka","family":"Dvorakova","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Cell Pathology, Third Faculty of Medicine Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Ivankova","sequence":"additional","affiliation":[{"name":"Institute for the Care of Mother and Child, Third Faculty of Medicine Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ladislav","family":"Krofta","sequence":"additional","affiliation":[{"name":"Institute for the Care of Mother and Child, Third Faculty of Medicine Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4396-3304","authenticated-orcid":false,"given":"Ilona","family":"Hromadnikova","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Cell Pathology, Third Faculty of Medicine Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.08.062554"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyl043"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11476-0"},{"key":"e_1_2_7_5_1","first-page":"343","article-title":"Etiologies of preterm birth in an indigent population: is prevention a logical expectation?","volume":"77","author":"Tucker JM","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2005.03.003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-199112000-00013"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.085"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00122-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70142-5"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.908179"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-305X(02)00160-X"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1999.277.5.L1026"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1998.4347"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.83.2.117"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(98)00028-X"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpb.2005.05.044"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.9.3919"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-008-0068-7"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-001-1131-3"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0306167"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.28.16510"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.16.4310"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2008.02.012"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-200204000-00001"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000086522.13672.23"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e31820fe704"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.4.1461"},{"issue":"1","key":"e_1_2_7_30_1","first-page":"121","article-title":"Heat shock proteins and their role in human diseases","volume":"59","author":"T\u00f3th ME","year":"2015","journal-title":"Acta Biol Szeged"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2001.010"},{"key":"e_1_2_7_32_1","first-page":"273","article-title":"HSP27 phosphorylation\u2010mediated resistance against actin fragmentation and cell death induced by oxidative stress","volume":"56","author":"Huot J","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399400002015"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/370111a0"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06956.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.49.32883"},{"key":"e_1_2_7_37_1","first-page":"177","article-title":"The role of the spiral arteries in the pathogenesis of preeclampsia","volume":"1","author":"Brosens I","year":"1972","journal-title":"Obstet Gynecol Annu"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700930219"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(80)90387-7"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00838-X"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1985.tb01045.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(87)80082-0"},{"key":"e_1_2_7_43_1","first-page":"578","article-title":"The correlation of arterial lesions with umbilical artery Doppler velocimetry in the placentas of small\u2010for\u2010dates pregnancies","volume":"75","author":"Fok RY","year":"1990","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90443-U"},{"key":"e_1_2_7_45_1","first-page":"383","article-title":"The prevalence and distribution of acute placental inflammation in uncomplicated term pregnancies","volume":"73","author":"Salafia CM","year":"1989","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701851372"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_7_48_1","first-page":"245","article-title":"ACOG guidelines on premature rupture of membranes","volume":"77","author":"Armstrong C","year":"2008","journal-title":"Am Fam Physician"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.02.011"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12220"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031136"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803053381006"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200301000-00033"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-014-3808-z"},{"key":"e_1_2_7_55_1","first-page":"137","volume-title":"Obstetrics and Gynecology","author":"Le J","year":"2008"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90499-9"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faji.12698","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.12698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:00:00Z","timestamp":1696338000000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.12698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,12]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/aji.12698"],"URL":"https:\/\/doi.org\/10.1111\/aji.12698","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,12]]},"article-number":"e12698"}}