{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:25:12Z","timestamp":1753878312817,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T00:00:00Z","timestamp":1494806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Universita di Bologna","award":["RFO Ricerca Fondamentale Orientata"],"award-info":[{"award-number":["RFO Ricerca Fondamentale Orientata"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>To compare placental protein 13 (<jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>13) levels in the serum of women with primary postpartum hemorrhage (<jats:styled-content style=\"fixed-case\">PPH<\/jats:styled-content>) with a control population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective cohort study was conducted between May 2014 and May 2016 and included 435 pregnant women at term (38\u00a0weeks gestation) without any known risk factor and with normal labor. Multiples of median (MoM) were used to evaluate differences of the <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>13 values between cases and controls. <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>13 concentrations were adjusted for maternal and neonatal weight. Multivariable analysis was used to detect independent contribution of predictors of <jats:styled-content style=\"fixed-case\">PPH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen had a major <jats:styled-content style=\"fixed-case\">PPH<\/jats:styled-content> &gt;1000\u00a0mLs and represented the cases of the study. They were matched with 399 controls. Twenty\u2010one patients who had a minor <jats:styled-content style=\"fixed-case\">PPH<\/jats:styled-content> (500\u20101000 <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>s) were excluded. The mean observed rank in the <jats:styled-content style=\"fixed-case\">PPH<\/jats:styled-content> group was higher than that of controls (28.5 vs 13.5, <jats:italic>P<\/jats:italic>\u2010value=.01). <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>13 MoM values adjusted for maternal weight were higher than expected being 1.44\u00b10.45 in <jats:styled-content style=\"fixed-case\">PPH<\/jats:styled-content> cases and 1.00\u00b10.59 in controls (<jats:italic>P<\/jats:italic>\u2010value .008). This difference was still significant even after adjustment for neonatal weight that represented a confounding variable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>13 levels are independently associated with major <jats:styled-content style=\"fixed-case\">PPH<\/jats:styled-content> &gt;1000\u00a0mLs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12702","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T04:12:43Z","timestamp":1494907963000},"source":"Crossref","is-referenced-by-count":3,"title":["Elevated maternal placental protein 13 serum levels at term of pregnancy in postpartum major hemorrhage (&gt;1000\u00a0mLs). A prospective cohort study"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-1810","authenticated-orcid":false,"given":"Antonio","family":"Farina","sequence":"first","affiliation":[{"name":"Division of Obstetrics and Gynecology St. Orsola\u2010Malpighi Polyclinic Department of Medical and Surgical Sciences (DIMEC) University of Bologna  Bologna BO Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalila","family":"Bernabini","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology St. Orsola\u2010Malpighi Polyclinic Department of Medical and Surgical Sciences (DIMEC) University of Bologna  Bologna BO Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Zucchini","sequence":"additional","affiliation":[{"name":"Department of Experimental Diagnostic and Specialty Medicine (DIMES) Unit of Histology Embryology and Applied Biology University of Bologna  Bologna BO Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"De Sanctis","sequence":"additional","affiliation":[{"name":"Department of Experimental Diagnostic and Specialty Medicine (DIMES) Unit of Histology Embryology and Applied Biology University of Bologna  Bologna BO Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Soledad","family":"Quezada","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Department of Obstetrics and Gynecology Hospital Universitario \u201c12 de Octubre\u201d Faculty of Medicine Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara","family":"Mattioli","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology St. Orsola\u2010Malpighi Polyclinic Department of Medical and Surgical Sciences (DIMEC) University of Bologna  Bologna BO Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology St. Orsola\u2010Malpighi Polyclinic Department of Medical and Surgical Sciences (DIMEC) University of Bologna  Bologna BO Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-005-0009-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000152760.34443.86"},{"key":"e_1_2_6_4_1","first-page":"69","article-title":"Factors associated with postpartum hemorrhage with vaginal birth","volume":"77","author":"Combs CA","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68397-9"},{"key":"e_1_2_6_6_1","unstructured":"RCOG. 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