{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:18:51Z","timestamp":1762867131117,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,5,20]],"date-time":"2017-05-20T00:00:00Z","timestamp":1495238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571391","30900847","31571189"],"award-info":[{"award-number":["81571391","30900847","31571189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDA01030000"],"award-info":[{"award-number":["XDA01030000"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>To define a more precise parameter for a better understanding of natural killer (<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>) cells and its relation with regulatory T cells (Tregs) in women with recurrent implantation failure (<jats:styled-content style=\"fixed-case\">RIF<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>The percentages of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>56+ cells, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>57+ cells and Foxp3+ cells in the endometrium and blood from 23 normal controls and 32 women with <jats:styled-content style=\"fixed-case\">RIF<\/jats:styled-content> were measured by immunocytochemistry and flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women with <jats:styled-content style=\"fixed-case\">RIF<\/jats:styled-content> had significantly increased ratio of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>57+ cells to <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>56+ cells in both the endometrium (<jats:italic>P<\/jats:italic>&lt;.01) and blood (<jats:italic>P<\/jats:italic>&lt;.05), and decreased percentage of Foxp3+ cells in the endometrium (<jats:italic>P<\/jats:italic>&lt;.05). There was a significant negative correlation between <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>57+ cells to <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>56+ cells ratio and the percentage of Foxp3+ cells in the blood of <jats:styled-content style=\"fixed-case\">RIF<\/jats:styled-content> patients (<jats:italic>P<\/jats:italic>&lt;.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study provides a novel assessment parameter, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>57+ cells to <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>56+ cells ratio, to evaluate <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells and its relation with Tregs in <jats:styled-content style=\"fixed-case\">RIF<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12708","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T21:17:49Z","timestamp":1495574269000},"source":"Crossref","is-referenced-by-count":24,"title":["Abnormal ratio of <scp>CD<\/scp>57<sup>+<\/sup> cells to <scp>CD<\/scp>56<sup>+<\/sup> cells in women with recurrent implantation failure"],"prefix":"10.1111","volume":"78","author":[{"given":"Ruiwei","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Center for Reproductive Medicine The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guijun","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Center for Reproductive Medicine The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing 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