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The placenta, as the nutrient and gas exchange organ, plays an essential role during this process. In addition, the interaction between trophoblast and maternal immune cells at the maternal\u2013fetal interface is also associated with successful pregnancy. Human leukocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>) molecules on trophoblast cells are involved in protecting the fetus from maternal rejection. Trophoblast cells comprise three subpopulations, including syncytiotrophoblast cells, cytotrophoblast cells, and extravillous trophoblast cells, and these cells express different <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> molecules. Syncytiotrophoblast and extravillous trophoblast cells encounter maternal immune cells from different sources, such as blood or decidua. The increased \u03b3\u03b4\u2010T cells during human normal pregnancy indicate that these cells may play a role in this process. In peripheral blood, V\u03b39V\u03b42\u2010T cells display cytotoxicity through the recognition of phosphoantigens derived from pathogens. However, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010E molecules protect the trophoblast cells from the cytotoxicity of V\u03b39V\u03b42\u2010T cells through binding to the inhibitory receptor, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>94\/<jats:styled-content style=\"fixed-case\">NKG<\/jats:styled-content>2A. In decidua, the main V\u03b41\u2010T cells maintain the pregnancy through the secretion of cytokines. In addition, the imbalance between V\u03b39V\u03b42\u2010T and V\u03b41\u2010T cells, and the abnormal expression of the receptors on \u03b3\u03b4\u2010T cells were observed in adverse pregnancy.<\/jats:p>","DOI":"10.1111\/aji.12713","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T05:59:27Z","timestamp":1498543167000},"source":"Crossref","is-referenced-by-count":19,"title":["The role of \u03b3\u03b4\u2010T cells during human pregnancy"],"prefix":"10.1111","volume":"78","author":[{"given":"Chunyu","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Paediatric and Adolescent Medicine Li Ka Shing Faculty of Medicine the University of Hong Kong  HongKong China"},{"name":"Shenzhen Key Laboratory of Reproductive Immunology for Peri\u2010implantation Shenzhen Zhongshan Urology of Hospital  Shenzhen Guangdong 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