{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:10:10Z","timestamp":1792213810807,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:00:00Z","timestamp":1496707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2016A020215024"],"award-info":[{"award-number":["2016A020215024"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300530"],"award-info":[{"award-number":["81300530"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2016A0202 15024"],"award-info":[{"award-number":["2016A0202 15024"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>The presence of dendritic cells (DCs) and associated cytokines in follicular fluid (FF) from patients with polycystic ovary syndrome (PCOS) remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods of study<\/jats:title><jats:p>FF was collected from PCOS patients and patients with severe male factor infertility (control) at the day of transvaginal oocyte retrieval. Phenotypes of DC were detected by flow cytometry, and TNF\u2010\u03b1, IL\u20106, IL\u201010, and IL\u201023 were assessed by ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant decrease in the percentage of DC was found in patients with PCOS (16.22\u00b15.5%) compared with control (21.27\u00b15.5%, <jats:italic>P<\/jats:italic>&lt;.01). E<jats:sub>2<\/jats:sub> on the day of hCG administration was correlated positively with the mean fluorescence intensity of HLA\u2010DR (<jats:italic>r<\/jats:italic>=.75, <jats:italic>P<\/jats:italic>&lt;.01) and reversely correlated with the concentration of TNF\u2010\u03b1 in FF (<jats:italic>r<\/jats:italic>=\u2212.69, <jats:italic>P<\/jats:italic>&lt;.01). The level of TNF\u2010\u03b1, IL\u20106, and IL\u201010 increased significantly but IL\u201023 decreased in FF from patients with PCOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The decrease of DC and disturbance of associated cytokines in FF from PCOS patients indicates a disorder of immunological microenvironment of the ovarian follicle, which might be involved in the dysfunction of folliculogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12717","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T11:42:42Z","timestamp":1496749362000},"source":"Crossref","is-referenced-by-count":49,"title":["Detection of dendritic cells and related cytokines in follicular fluid of patients with polycystic ovary syndrome"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8644-8468","authenticated-orcid":false,"given":"Tao","family":"Zhang","sequence":"first","affiliation":[{"name":"Fertility 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