{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:01:19Z","timestamp":1791910879507,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T00:00:00Z","timestamp":1497312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec>\n                    <jats:title>Problem<\/jats:title>\n                    <jats:p>The aim of this prospective study was to investigate the prevalence of chronic endometritis (CE) in infertile women with a history of repeated implantation failure (RIF) and to determine whether oral antibiotic treatment improves their live birth rate in the following embryo transfer (ET) cycles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method of study<\/jats:title>\n                    <jats:p>Endometrial biopsy samples obtained from infertile women with RIF were subjected to immunohistochemistrical\/histopathologic diagnosis of CE. Following antibiotic administration to the RIF\/CE group, their histopathologic cure rate, microbial detection rate, and reproductive outcome in the subsequent ET cycles were prospectively studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      33.7% of infertile women with RIF were diagnosed with CE. Following the first\u2010line doxycycline treatment, the histopathologic cure rate in the subsequent endometrial biopsy was 92.3%. Following the second\u2010line metronidazole\/ciprofloxacin treatment, the overall cure rate was 99.1%. The live birth rate in the first ET cycle (\n                      <jats:italic>P<\/jats:italic>\n                      =.031, RR 1.48, 95% CI 1.03\u20102.12) and cumulative three ET cycles (\n                      <jats:italic>P<\/jats:italic>\n                      =.037, RR 1.39, 95% CI 1.02\u20101.90) following antibiotic treatment in the cured RIF\/CE group (32.8% and 38.8%, respectively) was significantly higher than in the RIF\/non\u2010CE group (22.1% and 27.9%, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Chronic endometritis was found in one\u2010third of infertile women with RIF. The oral antibiotic treatment against CE might be a promising therapeutic option for infertile women with RIF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.12719","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T05:42:39Z","timestamp":1497332559000},"source":"Crossref","is-referenced-by-count":233,"title":["Live birth rate following oral antibiotic treatment for chronic endometritis in infertile women with repeated implantation failure"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5693-3139","authenticated-orcid":false,"given":"Kotaro","family":"Kitaya","sequence":"first","affiliation":[{"name":"Reproduction Clinic Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiko","family":"Matsubayashi","sequence":"additional","affiliation":[{"name":"Reproduction Clinic Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Takaya","sequence":"additional","affiliation":[{"name":"Reproduction Clinic Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Reproduction Clinic Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Reproduction Clinic Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Reproduction Clinic Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomoto","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Reproduction Clinic Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del305"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2013.08.011"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2011.01051.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.03.074"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.12.131"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des323"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.12.031"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719113508817"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.98"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.09.061"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.09.025"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12076"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12277"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.09.039"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu292"},{"key":"e_1_2_5_17_1","first-page":"121","volume-title":"Preembryo Grading","author":"Veeck LL","year":"1991"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00518-5"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880405"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.02.128"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2008.030486"},{"key":"e_1_2_5_22_1","first-page":"1581","article-title":"Barcoded sequencing reveals diverse intrauterine microbiomes in patients suffering with endometrial polyps","volume":"8","author":"Fang RL","year":"2016","journal-title":"Am J Transl Res"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000223819"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31825a6bc9"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2012.06.012"},{"key":"e_1_2_5_26_1","first-page":"CD009517","article-title":"Endometrial injury in women undergoing assisted reproductive techniques","volume":"3","author":"Nastri CO","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew053"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12438"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der092"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faji.12719","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.12719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T07:44:33Z","timestamp":1695973473000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.12719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,13]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/aji.12719"],"URL":"https:\/\/doi.org\/10.1111\/aji.12719","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,13]]},"article-number":"e12719"}}