{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:22:28Z","timestamp":1753878148412,"version":"3.41.2"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T00:00:00Z","timestamp":1498521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>It is unclear if the immunologic alterations induced by pregnancy could persist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Antenatal rubella sero\u2010negativity was correlated with gravidity, abortions and parity in 112\u00a0083 gravidae managed during 1997\u20102015, with further analysis stratified for factors known to influence rubella serology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 10.2% sero\u2010negative gravidae had different characteristics, and the incidence showed significant difference and positive trend (<jats:italic>P<\/jats:italic>&lt;.001 for both) with gravidity, abortions and parity. The pattern remained consistent when analysis was stratified for advanced age, high body mass index and medical history, but was negated by hepatitis B virus infection except for abortions, and by high body mass index for parity. For gravidity 2\u20104, no difference in rubella sero\u2010negativity was found between gravidae with all previous pregnancies ended in abortion vs delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prior pregnancies diminished rubella immunity in a dose\u2010dependent manner, which may be a reflection of the cumulative effect of pregnancy\u2010associated maternal immunologic alteration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12727","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T05:48:46Z","timestamp":1498542526000},"source":"Crossref","is-referenced-by-count":2,"title":["Prior pregnancy and antenatal rubella sero\u2010negativity\u2014evidence of persistent maternal immunologic alteration?"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7315-8747","authenticated-orcid":false,"given":"Terence T.","family":"Lao","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Prince of Wales Hospital The Chinese University of Hong Kong  Shatin Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie S. 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