{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T13:04:04Z","timestamp":1775307844172,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T00:00:00Z","timestamp":1505865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004329","name":"Javna Agencija za Raziskovalno Dejavnost RS","doi-asserted-by":"publisher","award":["P3\u20100326"],"award-info":[{"award-number":["P3\u20100326"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Aberrant <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> methylation has been suggested as a potential cause of recurrent spontaneous abortion (<jats:styled-content style=\"fixed-case\">RSA<\/jats:styled-content>). Considering the growing evidence on the important roles of <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> methylation in gametogenesis and early pregnancy, we investigated the potential association of <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> methyltransferase gene polymorphisms (<jats:styled-content style=\"fixed-case\">DNMT<\/jats:styled-content>1 rs2228611, <jats:styled-content style=\"fixed-case\">DNMT<\/jats:styled-content>3A rs1550117, <jats:styled-content style=\"fixed-case\">DNMT<\/jats:styled-content>3B rs1569686) with <jats:styled-content style=\"fixed-case\">RSA<\/jats:styled-content> in Slovenian reproductive couples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>A total of 146 couples with \u22653 consecutive spontaneous abortions and 149 control women and men with \u22652 normal pregnancies were included. Genotyping was performed using <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RFLP<\/jats:styled-content> methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found a statistically significant higher frequency of the <jats:styled-content style=\"fixed-case\">DNMT<\/jats:styled-content>3B rs1569686 <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> genotype (X<jats:sup>2<\/jats:sup>=7.37;<jats:italic>P<\/jats:italic>\u00a0=\u00a0.025) and G allele (X<jats:sup>2<\/jats:sup>\u00a0=\u00a06.33;<jats:italic>P<\/jats:italic>\u00a0=\u00a0.012) in <jats:styled-content style=\"fixed-case\">RSA<\/jats:styled-content> women compared with controls. Moreover, the odds for <jats:styled-content style=\"fixed-case\">RSA<\/jats:styled-content> in women were increased under the recessive genetic model (<jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content>vs<jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>:<jats:styled-content style=\"fixed-case\"> OR<\/jats:styled-content>=1.92; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>=1.18\u20103.09; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DNMT<\/jats:styled-content>3B rs1569686 gene polymorphism in women might be a genetic marker for the susceptibility to <jats:styled-content style=\"fixed-case\">RSA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12765","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T11:38:10Z","timestamp":1505907490000},"source":"Crossref","is-referenced-by-count":10,"title":["A Single Nucleotide Polymorphism of <scp>DNA<\/scp> methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion"],"prefix":"10.1111","volume":"78","author":[{"given":"Anita","family":"Bari\u0161i\u0107","sequence":"first","affiliation":[{"name":"Department of biology and medical genetics Faculty of medicine University of Rijeka  Rijeka Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6725-7618","authenticated-orcid":false,"given":"Nina","family":"Pereza","sequence":"additional","affiliation":[{"name":"Department of biology and medical genetics Faculty of medicine University of Rijeka  Rijeka 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